caa a22 4500 475846389 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00000691 doi (NATIONALLICENCE)springer-10.1007/PL00000691 Generation of cellular immune responses to antigenic tumor peptides [Elektronische Daten] [G. A. Pietersz*, V. Apostolopoulos, I. F. C. McKenzie] Abstract.: Tumor immunotherapy is currently receiving close scrutiny. However, with the identification of tumor antigens and their production by recombinant means, the use of cytokines and knowledge of major histocompatibility complex (MHC) class I and class II presentation has provided ample reagents for use and clear indications of how they should be used. At this time, much attention is focused on using peptides to be presented by MHC class I molecules to both induce and be targets for CD8+ cytolytic T cells. Many peptides generated endogenously or given exogenously can enter the class I pathway, but a number of other methods of entering this pathway are also known and are discussed in detail herein. While the review concentrates on inducing cytotoxic T cells (CTLs), it is becoming increasingly apparent that other modes of immunotherapy would be desirable, such as class II presentation to induce increased helper activity (for CTL), but also activating macrophages to be effective against tumor cells. Birkhäuser Verlag Basel,, 2000 Key words. Tumor antigens nationallicence vaccines nationallicence class I presentation nationallicence class II presentation nationallicence peptides nationallicence toxins nationallicence adjuvants nationallicence antigen targeting nationallicence clinical trials nationallicence CTL epitopes nationallicence Pietersz* G. A. The Austin Research Institute, Studley Rd, Heidelberg, Victoria, 3084 (Australia), AL aut Apostolopoulos V. Department of Molecular Biology, Scripps Research Institute, 10550 Nth Torrey Pines Rd (BCC-206), La Jolla (California 92037, USA), Fax +1 613 9287 0600, e-mail: g.pietersz@ari.unimelb.edu.au, US aut McKenzie I. F. C. The Austin Research Institute, Studley Rd, Heidelberg, Victoria, 3084 (Australia), AL aut https://doi.org/10.1007/PL00000691 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000691 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pietersz* G. A. The Austin Research Institute, Studley Rd, Heidelberg, Victoria, 3084 (Australia), AL aut NATIONALLICENCE 700 1- Apostolopoulos V. Department of Molecular Biology, Scripps Research Institute, 10550 Nth Torrey Pines Rd (BCC-206), La Jolla (California 92037, USA), Fax +1 613 9287 0600, e-mail: g.pietersz@ari.unimelb.edu.au, US aut NATIONALLICENCE 700 1- McKenzie I. F. C. The Austin Research Institute, Studley Rd, Heidelberg, Victoria, 3084 (Australia), AL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer