caa a22 4500 475846435 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00000685 doi (NATIONALLICENCE)springer-10.1007/PL00000685 Determination of vertebrate retinal progenitor cellfate by the Notch pathway and basic helix-loop-helixtranscription factors [Elektronische Daten] [M. Perron, W. A. Harris*] Abstract.: The retina is an excellent system in which to study neural cell fate decision mechanisms. It is an organized laminated structure with a limited array of cell types. During the last 5 years, experiments that perturb normal gene expression have highlighted some molecular mechanisms involved in cellular fate choice in the retina. By controlling when a retinoblast is allowed to differentiate, Delta-Notch signaling plays a critical role in the generation of neuronal diversity in the vertebrate retina. When cells are released from the inhibition mediated by the Delta-Notch pathway, basic helix-loop-helix (bHLH) transcription factors act as intrinsic factors that bias neuroblasts towards particular fates. In this review, we present an overview of the data leading to these conclusions on the role of the Delta-Notch pathway and the bHLH proteins on cell fate decisions during vertebrate retinogenesis. Birkhäuser Verlag Basel,, 2000 Key words. Retina nationallicence neurogenesis nationallicence bHLH transcription factors nationallicence proneural genes nationallicence Delta-Notch pathway nationallicence neurogenic genes nationallicence cell determination nationallicence Perron M. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY (UK), Fax +44 1223 333 786, e-mail: harris@mole.bio.cam.ac.uk, UA aut Harris* W. A. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY (UK), Fax +44 1223 333 786, e-mail: harris@mole.bio.cam.ac.uk, UA aut https://doi.org/10.1007/PL00000685 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000685 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perron M. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY (UK), Fax +44 1223 333 786, e-mail: harris@mole.bio.cam.ac.uk, UA aut NATIONALLICENCE 700 1- Harris* W. A. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY (UK), Fax +44 1223 333 786, e-mail: harris@mole.bio.cam.ac.uk, UA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer