caa a22 4500 475846508 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000643 doi (NATIONALLICENCE)springer-10.1007/PL00000643 Regulation of receptor function by cholesterol [Elektronische Daten] [K. Burger, G. Gimpl, F. Fahrenholz] Abstract.: Cholesterol influences many of the biophysical properties of membranes and is nonrandomly distributed between cellular organelles, subdomains of membranes, and leaflets of the membrane bilayer. In combination with the high dynamics of cholesterol distribution, this offers many possibilities for regulation of membrane-embedded receptors. Depending on the receptor, cholesterol can have a strong influence on the affinity state, on the binding capacity, and on signal transduction. Most important, cholesterol may stabilize receptors in defined conformations related to their biological functions. This may occur by direct molecular interaction between cholesterol and receptors. In this review, we discuss the functional dependence of the nicotinic acetylcholine receptor as well as different G protein-coupled receptors on the presence of cholesterol. Birkhäuser Verlag Basel,, 2000 Key words. Rhodopsin nationallicence oxytocin nationallicence cholecystokinin nationallicence galanin nationallicence phospholipid nationallicence membrane fluidity nationallicence calcium measurement nationallicence Burger K. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut Gimpl G. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut Fahrenholz F. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut https://doi.org/10.1007/PL00000643 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000643 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burger K. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut NATIONALLICENCE 700 1- Gimpl G. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut NATIONALLICENCE 700 1- Fahrenholz F. Institut für Biochemie, Johannes Gutenberg-Universität Mainz, Becherweg 30, 55099 Mainz (Germany), Fax +49 6131 3925348, e-mail: ibc1950@mail.uni-mainz.de, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer