caa a22 4500 475846516 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000636 doi (NATIONALLICENCE)springer-10.1007/PL00000636 Localization and stabilization of ionotropic glutamate receptors at synapses [Elektronische Daten] [M.M. Bolton, T.A. Blanpied, M.D. Ehlers] Abstract.: Appropriate targeting and clustering of ionotropic glutamate receptors (iGluRs) is critical for the formation and maintenance of excitatory synapses. Recent studies have demonstrated that the synaptic localization of iGluR subtypes is remarkably heterogeneous and subject to regulation over time scales ranging from minutes to months. These findings, together with the identification of key protein binding partners of iGluRs, have opened a window onto the complex cell biology of iGluR membrane trafficking. In this article, we review recent findings on the cellular and molecular mechanisms involved in localizing iGluRs at synapses and discuss their implications for synaptogenesis and synaptic plasticity. Birkhäuser Verlag Basel,, 2000 Key words. Glutamate receptor nationallicence synapse nationallicence membrane targeting nationallicence plasticity nationallicence synaptic transmission nationallicence synaptogenesis nationallicence cytoskeleton nationallicence Bolton M.M. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut Blanpied T.A. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut Ehlers M.D. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut https://doi.org/10.1007/PL00000636 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000636 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bolton M.M. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut NATIONALLICENCE 700 1- Blanpied T.A. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut NATIONALLICENCE 700 1- Ehlers M.D. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham (North Carolina 27710, USA), Fax +1 919 684 4431, e-mail: ehlers@neuro.duke.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer