caa a22 4500 475846524 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000635 doi (NATIONALLICENCE)springer-10.1007/PL00000635 The role of glycosylation in ionotropic glutamate receptor ligand binding, function, and trafficking [Elektronische Daten] [S. Standley, M. Baudry] Abstract.: Members of the ionotropic glutarnate receptor (iGluR) family have between 4 and 12 consensus asparagine (N)-linked glycosylation sites. They are localized on the extracellular N-termini, and the loop between the penultimate and last transmembrane domains. These regions also contain the essential elements for formation of the ligand binding site. N-linked glycosylation does not appear to be essential for formation of the ligand binding site per se, but there are demonstrated interactions between glycosylation state and ligand binding affinity, receptor physiology, susceptibility to allosteric modulation and, in some cases, trafficking. There is no indication of a general role for N-linked glycosylation in iGluRs; instead the effects of glycosylation vary among glutamate receptor subtypes and splice variants, with specific effects on structure or function with different subunits. Birkhäuser Verlag Basel,, 2000 Key words. Glutamate nationallicence receptors nationallicence glycosylation nationallicence ionotropic nationallicence asparagine-linked nationallicence Standley S. Laboratory of Neurochemistry, Bldg. 36, Rm. 51308, NIDCD, National Institute of Health, Bethesda (Maryland 20892, USA), US aut Baudry M. Neuroscience Program, University of Southern California, Los Angeles (California, 90089-2520, USA), US aut https://doi.org/10.1007/PL00000635 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000635 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Standley S. Laboratory of Neurochemistry, Bldg. 36, Rm. 51308, NIDCD, National Institute of Health, Bethesda (Maryland 20892, USA), US aut NATIONALLICENCE 700 1- Baudry M. Neuroscience Program, University of Southern California, Los Angeles (California, 90089-2520, USA), US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer