caa a22 4500 475846575 CHVBK 20180406123915.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000638 doi (NATIONALLICENCE)springer-10.1007/PL00000638 Redox modulation of the NMDA receptor [Elektronische Daten] [Y.-B. Choi, S.A. Lipton] Abstract.: Redox modulation has been recognized to be an important mechanism of regulation for the N-methyl-d-aspartate (NMDA) receptor. Sulfhydryl reducing agents enhance, whereas oxidizing agents decrease, NMDA-evoked currents. Multiple cysteine residues located in different NMDA receptor subunits have been identified as molecular determinants underlying redox modulation. The NMDA receptor is also regulated by nitric oxide (NO)-related species directly, not involving cyclic GMP, but the molecular mechanism of this action has heretofore not been entirely clear. The confusion arose at least partly due to the fact that various redox forms of NO (NO+, NO•, NO−, each having an additional electron compared with the previous) have distinct mechanisms of action. Recently, a critical cysteine residue (Cys 399) on the NR2A subunit has been shown to react under physiological conditions with NO by S-nitrosylation (transfer of the NO+ to cysteine thiol) or by reaction with NO− (nitroxyl anion) to underlie this form of modulation. Birkhäuser Verlag Basel,, 2000 Key words. NMDA receptor nationallicence redox nationallicence DTT nationallicence nitric oxide nationallicence S-nitrosylation nationallicence cysteine nationallicence Choi Y.-B CNS Research Institute, Brigham and Women's Hospital and Program in Neuroscience, Harvard Medical School, Boston (Massachusetts 02115, USA), US aut Lipton S.A. CNS Research Institute, Brigham and Women's Hospital and Program in Neuroscience, Harvard Medical School, Boston (Massachusetts 02115, USA), US aut https://doi.org/10.1007/PL00000638 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000638 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choi Y.-B CNS Research Institute, Brigham and Women's Hospital and Program in Neuroscience, Harvard Medical School, Boston (Massachusetts 02115, USA), US aut NATIONALLICENCE 700 1- Lipton S.A. CNS Research Institute, Brigham and Women's Hospital and Program in Neuroscience, Harvard Medical School, Boston (Massachusetts 02115, USA), US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer