caa a22 4500 475846605 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000640 doi (NATIONALLICENCE)springer-10.1007/PL00000640 The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy [Elektronische Daten] [D.M. Kullmann, F. Asztely, M.C. Walker] Abstract.: Synaptic plasticity is the foremost candidate mechanism to explain the rapid acquisition of memories. In the mammalian brain, the NMDA subclass of glutamate receptors plays a central role in the induction of several forms of use-dependent plasticity. The finding that modifications in synaptic strength are largely expressed by receptors of the AMPA subclass has focused attention on molecular mechanisms that affect their function and targeting. Receptor plasticity has also been reported in pathological situations, notably in animal and human forms of epilepsy. Which of these changes are causally implicated in the generation of seizures, and which may be compensatory or neuroprotective adaptations, has not been fully resolved. Birkhäuser Verlag Basel,, 2000 Key words. AMPA nationallicence NMDA nationallicence kainate nationallicence GABA nationallicence receptor subunits nationallicence phosphorylation nationallicence silent synapses nationallicence status epilepticus nationallicence Kullmann D.M. University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom), GB aut Asztely F. Section of Restorative Neurology, Wallenberg Neuroscience Center, Department of Clinical Neuroscience, Lund University Hospital, Lund S-221 85 (Sweden), SE aut Walker M.C. University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom), GB aut https://doi.org/10.1007/PL00000640 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000640 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kullmann D.M. University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom), GB aut NATIONALLICENCE 700 1- Asztely F. Section of Restorative Neurology, Wallenberg Neuroscience Center, Department of Clinical Neuroscience, Lund University Hospital, Lund S-221 85 (Sweden), SE aut NATIONALLICENCE 700 1- Walker M.C. University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom), GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer