caa a22 4500 475846613 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000634 doi (NATIONALLICENCE)springer-10.1007/PL00000634 Genomic control of receptor function [Elektronische Daten] [N. Burnashev, A. Rozov] Abstract.: Ionotropic ligand-gated channels constitute a large superfamily of channels that provide a molecular basis for synaptic transmission in central and peripheral nervous systems. These channels are subjects of genomic regulation at different levels. The final functional properties of each particular channel are determined by type of gene family, posttranscriptional alterations of messenger RNA (alternative splicing, editing) and subunit composition. In addition, interaction of receptor subunits with postsynaptic density proteins plays a regulatory role and determines targets of channel insertion. In this review, taking glutamate receptor channels as well-studied example, we illustrate how each of these steps may determine receptor function in synapses. Birkhäuser Verlag Basel,, 2000 Key words. Ionotropic glutamate receptor channels nationallicence alternative splicing nationallicence mRNA editing nationallicence synaptic transmission nationallicence Burnashev N. Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg (Germany), Fax +49 06221 486 459, e-mail: nail@sunny.mpimf-heidelberg.mpg.de, DE aut Rozov A. Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg (Germany), Fax +49 06221 486 459, e-mail: nail@sunny.mpimf-heidelberg.mpg.de, DE aut https://doi.org/10.1007/PL00000634 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000634 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burnashev N. Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg (Germany), Fax +49 06221 486 459, e-mail: nail@sunny.mpimf-heidelberg.mpg.de, DE aut NATIONALLICENCE 700 1- Rozov A. Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg (Germany), Fax +49 06221 486 459, e-mail: nail@sunny.mpimf-heidelberg.mpg.de, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer