caa a22 4500 475846621 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000637 doi (NATIONALLICENCE)springer-10.1007/PL00000637 Intracellular trafficking of AMPA receptors in synaptic plasticity [Elektronische Daten] [H.-Y. Man, W. Ju, G. Ahmadian, Y. T. Wang] Abstract.: Modification of ligand-gated receptor function at the postsynaptic domain is one of the most important mechanisms by which the efficacy of synaptic transmission in the nervous system is regulated. Traditionally, these types of modifications have been thought to be achieved mainly by altering the channel-gating properties or conductance of the receptors. However, recent evidence suggests that AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxayolepropionic acid)-type ligand-gated glutamate receptors are continuously recycling between the plasma membrane and the intracellular compartments via vesicle-mediated plasma membrane insertion and clathrin-dependent endocytosis. Regulation of either receptor insertion or endocytosis results in a rapid change in the number of these receptors expressed on the plasma membrane surface and in the receptor-mediated responses, thereby playing an important role in mediating certain forms of synaptic plasticity. Thus, controlling the number of postsynaptic receptors by regulating the intracellular trafficking and plasma membrane expression of the postsynaptic receptors may be a common and important mechanism of synaptic plasticity in the mammalian central nervous system. Birkhäuser Verlag Basel,, 2000 Key words. Exocytosis nationallicence endocytosis nationallicence protein trafficking nationallicence AMPA receptor nationallicence synaptic plasticity nationallicence Man H.-Y Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut Ju W. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut Ahmadian G. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut Wang Y. T. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut https://doi.org/10.1007/PL00000637 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000637 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Man H.-Y Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut NATIONALLICENCE 700 1- Ju W. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut NATIONALLICENCE 700 1- Ahmadian G. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut NATIONALLICENCE 700 1- Wang Y. T. Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer