caa a22 4500 475846648 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00000644 doi (NATIONALLICENCE)springer-10.1007/PL00000644 Gene structure and function of the 2′-5′-oligoadenylate synthetase family [Elektronische Daten] [J. Justesen, R. Hartmann, N.O. Kjeldgaard] Abstract.: 2′-5′-Oligoadenylate synthetase was among the first interferon-induced antiviral enzymes to be discovered. This family of enzymes plays an important role in the mechanisms of action of interferon antiviral activity, but is also involved in other cellular processes such as apoptosis and growth control. We have reviewed the function and genomic structure of this class of at least nine proteins. By studying the recently available data in the human genome database and the human Expressed Sequence Tag database, we have been able to build a comprehensive picture of the 2′-5′-oligoadenylate synthetase gene family and its precise location on chromosome 12. Chromosomal localization as well as the intron/exon structure of all four genes has been established and an overview of the splice variant forms of the 2′-5′-oligoadenylate synthetases arising from expression of the four genes is presented. Alignments of the human 2′-5′-oligoadenylate synthetase sequences with non-human 2′-5′-oligoadenylate synthetase sequences suggest that the exon structure and several amino acid sequence motifs have been conserved during evolution. Birkhäuser Verlag Basel,, 2000 Key words. Oligoadenylate synthetase nationallicence OAS nationallicence OASL nationallicence 2-5A nationallicence chromosome 12 nationallicence exon structure nationallicence OAS genes nationallicence Justesen J. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut Hartmann R. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut Kjeldgaard N.O. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut https://doi.org/10.1007/PL00000644 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00000644 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Justesen J. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut NATIONALLICENCE 700 1- Hartmann R. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut NATIONALLICENCE 700 1- Kjeldgaard N.O. Department of Molecular and Structural Biology, Aarhus University, CF Møllers Allé 130, DK-8000 Aarhus (Denmark), Fax +45 8942 2637, e-mail: JJ@mbio.au.dk, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer