caa a22 4500 475846702 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008986826756 doi (NATIONALLICENCE)springer-10.1023/A:1008986826756 Measuring the impact of onychomycosis on patient quality of life [Elektronische Daten] [Ralph Turner, Marcia Testa] According to survey research, onychomycosis, a fungal infection of the toenail or fingernail, affects quality of life including physical and social functioning and emotional health. We developed an onychomycosis disease-specific questionnaire (ODSQ) that sensitively assessed symptom distress, functional impact, and social stigma associated with the disease. Samples of patients enrolled in a randomized controlled clinical trial were used for the psychometric evaluations. The multi-item scales were internally consistent (α ≥ 0.80) and reproducible (ICC > 0.85). Interscale correlations between the ODSQ and generic scales were moderate and consistent with the hypothesized magnitude and directions. Construct validation, employing known groups analysis, supported the hypothesized impact of onychomycosis on three domains of quality of life: physical functioning, emotional health, and social functioning. Significant differences were found between clinically "cured”, "improved”, or "failed” patients, and between mycologically "eradicated” and "persistent” patients. The ODSQ was responsive to clinical change and more sensitive than derived Medical Outcomes Study Short Form-36 scales. The ODSQ provides reliable, validated and responsive information about the consequences of onychomycosis and its treatment. Kluwer Academic Publishers, 2000 Disease-specific scale nationallicence Generic scale nationallicence Onychomycosis nationallicence Quality of life nationallicence Reliability nationallicence Responsiveness nationallicence Validity nationallicence Turner Ralph Phase V Technologies, Inc., Wellesley Hills, Massachusetts aut Testa Marcia Phase V Technologies, Inc., Wellesley Hills, Massachusetts aut Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 39-53 0962-9343 9:1<39 2000 9 11136 https://doi.org/10.1023/A:1008986826756 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008986826756 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Turner Ralph Phase V Technologies, Inc., Wellesley Hills, Massachusetts aut NATIONALLICENCE 700 1- Testa Marcia Phase V Technologies, Inc., Wellesley Hills, Massachusetts aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 39-53 0962-9343 9:1<39 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer