caa a22 4500 475846737 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008952602494 doi (NATIONALLICENCE)springer-10.1023/A:1008952602494 Development and testing of a utility measure for major, unipolar depression (McSad) [Elektronische Daten] [K.J. Bennett, G.W. Torrance, M.H. Boyle, R. Guscott, L.A. Moran] Objective: To develop and test a direct utility measure (McSad) for major, unipolar depression. Methods: A depression specific, multi-attribute health state classification system was created; clinical validity was evaluated by experts using specially designed structured exercises; a cross-sectional survey was conducted to obtain directly measured utilities for depression health states. Setting: Tertiary care, university medical centre. Participants: Three psychiatrists, 3 psychiatric nurses and 3 social workers assessed depression health state clinical validity. Survey participants were referred by psychiatrists and consisted of 105 out-patients, currently in remission with at least one episode of major, unipolar depression in the past two years. Survey results: Respondent self-health state utility (mean and 95% confidence interval (CI)) was 0.79 (0.74-0.83). Utilities for hypothetical, untreated depression health states were: mild depression, 0.59 (0.55-0.62); moderate depression, 0.32 (0.29-0.34); severe depression, 0.04 (0.01-0.07). Fifty-six percent of respondents rated severe depression worse than being dead. Utilities for the hypothetical health states were not correlated with self-health utility. The intra-class correlation coefficient (ICC) was satisfactory for 13 of the 14 health states assessed. Conclusions: McSad was feasible and acceptable in patients with a history of major unipolar depression. The utilities for mild, moderate and severe untreated depression show the low health-related quality of life associated with depression. Initial assessments of test-retest reliability and validity yielded satisfactory results but further studies are needed to extend our knowledge of the measurement properties of McSad. Kluwer Academic Publishers, 2000 Cross-sectional survey nationallicence McSad nationallicence Tertiary care nationallicence Unipolar depression nationallicence Utility measures nationallicence Bennett K.J. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut Torrance G.W. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut Boyle M.H. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut Guscott R. Department of Psychiatry, University of Toronto, Toronto, Canada aut Moran L.A. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 109-120 0962-9343 9:1<109 2000 9 11136 https://doi.org/10.1023/A:1008952602494 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008952602494 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bennett K.J. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut NATIONALLICENCE 700 1- Torrance G.W. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut NATIONALLICENCE 700 1- Boyle M.H. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut NATIONALLICENCE 700 1- Guscott R. Department of Psychiatry, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Moran L.A. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 109-120 0962-9343 9:1<109 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer