caa a22 4500 475846753 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008928321652 doi (NATIONALLICENCE)springer-10.1023/A:1008928321652 Evaluation of a measurement strategy for Parkinson's disease: Assessing patient health-related quality of life [Elektronische Daten] [A.M. Damiano, M.M. McGrath, M.K. Willian, C.F. Snyder, P.A. LeWitt, P.F. Reyes, R.R. Richter, E.D. Means] This study evaluated the feasibility and psychometric properties of self-completed and telephone interview versions of a patient health-related quality-of-life (HQL) questionnaire for Parkinson's disease that included the SF-36 Health Survey (SF-36), the Parkinson's Disease Questionnaire (PDQ-39), and the Medical Outcomes Study Sexual Function Survey. Parkinson's disease patients (n = 150) completed the questionnaire twice: once at the study site and once over the telephone in a randomized order. Ninety-four percent of enrolled patients completed the first HQL assessment and 88% completed both assessments. Cronbach's α exceeded 0.70 for all scales except for the self-completed PDQ-39 Social Support subscale (0.57) and the telephone interview PDQ-39 Social Support (0.60) and Cognitions (0.67) subscales and the SF-36 General Health (0.60) and Social Function (0.61) subscales. There were no statistically significant differences in mean HQL scale scores across the two modes of administration. Mean scores for 3 of the PDQ-39 subscales and the Summary Index were significantly poorer (p < 0.05) for patients at later clinical stages. Similarly, patients with dyskinesias reported significantly poorer scores for 4 of the PDQ-39 subscales and the Summary Index and patients with self-reported comorbidities reported poorer SF-36 Physical Function and General Health subscale scores than patients without dyskinesias and comorbidities, respectively. This study suggests that the self-completed and telephone interview versions of the patient HQL questionnaire are feasible and valid for future clinical trial applications. Kluwer Academic Publishers, 2000 Health status nationallicence Mode of administration nationallicence Parkinson's disease nationallicence Psychometrics nationallicence Quality of life nationallicence Damiano A.M. Covance Health Economics and Outcomes Services Inc., Washington, DC aut McGrath M.M. Covance Health Economics and Outcomes Services Inc., Washington, DC aut Willian M.K. Astra Pharmaceuticals, L.P., Wayne, PA aut Snyder C.F. Covance Health Economics and Outcomes Services Inc., Washington, DC aut LeWitt P.A. Clinical Neuroscience Center, West Bloomfield, MI aut Reyes P.F. Jefferson Medical College, Philadelphia, PA aut Richter R.R. Clinical Pharmaceutical Trials, Inc., Tulsa, OK aut Means E.D. Astra Pharmaceuticals, L.P., Wayne, PA aut Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 87-100 0962-9343 9:1<87 2000 9 11136 https://doi.org/10.1023/A:1008928321652 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008928321652 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Damiano A.M. Covance Health Economics and Outcomes Services Inc., Washington, DC aut NATIONALLICENCE 700 1- McGrath M.M. Covance Health Economics and Outcomes Services Inc., Washington, DC aut NATIONALLICENCE 700 1- Willian M.K. Astra Pharmaceuticals, L.P., Wayne, PA aut NATIONALLICENCE 700 1- Snyder C.F. Covance Health Economics and Outcomes Services Inc., Washington, DC aut NATIONALLICENCE 700 1- LeWitt P.A. Clinical Neuroscience Center, West Bloomfield, MI aut NATIONALLICENCE 700 1- Reyes P.F. Jefferson Medical College, Philadelphia, PA aut NATIONALLICENCE 700 1- Richter R.R. Clinical Pharmaceutical Trials, Inc., Tulsa, OK aut NATIONALLICENCE 700 1- Means E.D. Astra Pharmaceuticals, L.P., Wayne, PA aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/1(2000-02-01), 87-100 0962-9343 9:1<87 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer