caa a22 4500 475846893 CHVBK 20180406123916.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1016668802328 doi (NATIONALLICENCE)springer-10.1023/A:1016668802328 Health-related Quality of Life and Virologic outcomes in an HIV Clinic [Elektronische Daten] [S.A. Call, J.C. Klapow, K.E. Stewart, A.O. Westfall, A.P. Mallinger, R.A. DeMasi, R. Centor, M.S. Saag] Objective: The purpose of this study was to describe the relationship between viral load and health-related quality of life (HRQOL) in a cohort of persons with human immunodeficiency virus (HIV) infection. Design: We evaluated HRQOL measurements in a clinical cohort of HIV-positive patients recruited from a university-associated HIV primary care clinic. HRQOL instruments included the medical outcomes survey-short form-36(MOS-SF-36) from which mental and physical component summary scores (MCS and PCS) and subscale scores were calculated. Results: Significant negative associations were found between viral load and SF-36 PCS, physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), role-emotional (RE), and vitality (VT). Similar negative associations were found between CD4 cell count and SF-36 summary and subscale scores, with the notable exception of bodily pain. Multivariate analyses controlling for the effects of CD4 cell count and other clinical variables indicated viral load as an independent predictor of SF-36 PCS, RP, BP and VT scores. Conclusions: The relationship between viral load, a measure of HIV disease activity, and several dimensions of the SF-36, a patient-focused measure of HRQOL, appears to be strong and independent of CD4 cell count. These findings suggest that having a lower viral load positively impacts the quality of life of HIV-positive patients. Kluwer Academic Publishers, 2000 AIDS nationallicence Health-related quality of life nationallicence HIV nationallicence SF-36 nationallicence Call S.A. Division of General Internal Medicine, Birmingham Veterans Administration, USA aut Klapow J.C. Department of Health Care Organization and Policy, USA aut Stewart K.E. Division of Infectious Diseases, USA aut Westfall A.O. Biostatistics Unit, University of Alabama at Birmingham, Birmingham, AL, USA aut Mallinger A.P. Department of Health Care Organization and Policy, USA aut DeMasi R.A. Glaxo Wellcome, USA aut Centor R. Division of General Internal Medicine, USA aut Saag M.S. Division of Infectious Diseases, USA aut Quality of Life Research Kluwer Academic Publishers 9/9(2000-11-01), 977-985 0962-9343 9:9<977 2000 9 11136 https://doi.org/10.1023/A:1016668802328 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1016668802328 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Call S.A. Division of General Internal Medicine, Birmingham Veterans Administration, USA aut NATIONALLICENCE 700 1- Klapow J.C. Department of Health Care Organization and Policy, USA aut NATIONALLICENCE 700 1- Stewart K.E. Division of Infectious Diseases, USA aut NATIONALLICENCE 700 1- Westfall A.O. Biostatistics Unit, University of Alabama at Birmingham, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Mallinger A.P. Department of Health Care Organization and Policy, USA aut NATIONALLICENCE 700 1- DeMasi R.A. Glaxo Wellcome, USA aut NATIONALLICENCE 700 1- Centor R. Division of General Internal Medicine, USA aut NATIONALLICENCE 700 1- Saag M.S. Division of Infectious Diseases, USA aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/9(2000-11-01), 977-985 0962-9343 9:9<977 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer