caa a22 4500 475847113 CHVBK 20180406123917.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1016658004947 doi (NATIONALLICENCE)springer-10.1023/A:1016658004947 Practice and Policy of Measuring Quality of Life and Health Economics in Cancer Clinical Trials: A Survey among Co-operative Trial Groups [Elektronische Daten] [G. Kiebert, S. Wait, J. Bernhard, A. Bezjak, D. Cella, R. Day, J. Houghton, C. Moinpour, C. Scott, R. Stephens] Background: Co-operative groups have played an important role in the advance of health-related quality of life (HRQL) research. However, definitions of the concept, criteria for selection of existing instruments and methods for data collection and interpretation remain poorly defined in the literature. A survey was conducted amongst the major cancer co-operative groups in order to gain a better understanding of their current policy and processes to ensure optimal HRQL data collection within cancer clinical trials. The topic of health economics was similarly addressed. Methods: A written questionnaire was addressed to 16 major European and North American cancer co-operative groups. Eleven groups responded (response rate: 69%), however, one group could not provide information for the survey, thus ten questionnaires were available for analysis. Results: The results from this survey among co-operative groups show that HRQL (more than health economics) is recognized as an important, although usually secondary, outcome measure in oncology trials. On the whole, co-operative groups have a rather flexible policy towards the inclusion of HRQL (and HE) into their clinical trials, and practice is very much on a case-by-case basis, but use standard practice guidelines and internal procedures is to ensure well-defined study protocols and enhance good quality studies. Kluwer Academic Publishers, 2000 Cancer nationallicence Co-operative group nationallicence Health economics nationallicence Randomized controlled clinical trials nationallicence Quality of life nationallicence Kiebert G. MEDTAP International, London, UK aut Wait S. Quality of life Taskforce in Oncology, Novartis Pharma, Basel, Switzerland aut Bernhard J. Swiss Group for Clinical Cancer Research, International Breast Cancer Study Group, Bern, Switzerland aut Bezjak A. Clinical Trials Group, National Cancer Institute of Canada, Toronto, Ontario, Canada aut Cella D. Eastern Cooperative Oncology Group, Evanston, IL, USA aut Day R. Bowel Project, National Surgical Adjuvant Breast, Pittsburgh, PA, USA aut Houghton J. Cancer Research Council, UCL Cancer Trials Centre, London, UK aut Moinpour C. Southwest Oncology Group, Seattle, WA, USA aut Scott C. Radiation Therapy Oncology Group, Philadelphia, PA, USA aut Stephens R. Clinical Trial Unit, Medical Research Council, London, UK aut Quality of Life Research Kluwer Academic Publishers 9/10(2000-12-01), 1073-1080 0962-9343 9:10<1073 2000 9 11136 https://doi.org/10.1023/A:1016658004947 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1016658004947 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kiebert G. MEDTAP International, London, UK aut NATIONALLICENCE 700 1- Wait S. Quality of life Taskforce in Oncology, Novartis Pharma, Basel, Switzerland aut NATIONALLICENCE 700 1- Bernhard J. Swiss Group for Clinical Cancer Research, International Breast Cancer Study Group, Bern, Switzerland aut NATIONALLICENCE 700 1- Bezjak A. Clinical Trials Group, National Cancer Institute of Canada, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Cella D. Eastern Cooperative Oncology Group, Evanston, IL, USA aut NATIONALLICENCE 700 1- Day R. Bowel Project, National Surgical Adjuvant Breast, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Houghton J. Cancer Research Council, UCL Cancer Trials Centre, London, UK aut NATIONALLICENCE 700 1- Moinpour C. Southwest Oncology Group, Seattle, WA, USA aut NATIONALLICENCE 700 1- Scott C. Radiation Therapy Oncology Group, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Stephens R. Clinical Trial Unit, Medical Research Council, London, UK aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/10(2000-12-01), 1073-1080 0962-9343 9:10<1073 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer