caa a22 4500 475847407 CHVBK 20180406123918.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1023/A:1008985728271 doi (NATIONALLICENCE)springer-10.1023/A:1008985728271 Health related quality of life among persons with HIV after the use of protease inhibitors [Elektronische Daten] [S. Low-Beer, K. Chan, E. Wood, B. Yip, J.S.G. Montaner, M.V. O'Shaughnessy, R.S. Hogg] Objective: This study was conducted to determine the effect of the use of HIV protease inhibitors on the quality of life among persons infected with HIV. Methods: Subjects were participants in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program who had completed two annual participant surveys, one prior to initiating therapy with a protease inhibitor and one after. Quality of life was measured using the Medical Outcomes Study Short Form Health Survey (MOS-SF). Statistical analyses were conducted using parametric and multivariate methods. Results: Our analysis was based on 179 HIV-positive individuals. Compared to quality of life at baseline, we found no statistically significant changes in the health perception, pain, physical, role and social functioning MOS-SF subscale scores at follow-up. The measure of mental health was the only component to decline significantly over time. Sub-analyses found significant increases in the measures of health perception (p = 0.004), physical (p = 0.037), role (p < 0.001) and social functioning (p = 0.053) for individuals with a low baseline quality of life. For those with a higher quality of life before starting a protease inhibitor containing regimen we observed a significant decline in the subscales of mental health (p = 0.001), physical (p = 0.007), role (p = 0.021) and social functioning (p = 0.003) over the study period. Conclusions: Our findings indicate that despite strict dosage requirements and adverse side effects associated with protease inhibitor use patients are on the whole maintaining their quality of life after starting on a protease inhibitor containing regimen. Continued follow-up of this cohort will be required to determine the long term implications of these observations. Kluwer Academic Publishers, 2000 Antiretroviral therapy nationallicence Canada nationallicence HIV/AIDS nationallicence Protease inhibitors nationallicence Quality of life nationallicence Low-Beer S. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Chan K. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Wood E. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Yip B. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Montaner J.S.G. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut O'Shaughnessy M.V. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Hogg R.S. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut Quality of Life Research Kluwer Academic Publishers 9/8(2000-09-01), 941-949 0962-9343 9:8<941 2000 9 11136 https://doi.org/10.1023/A:1008985728271 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008985728271 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Low-Beer S. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- Chan K. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- Wood E. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- Yip B. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- Montaner J.S.G. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- O'Shaughnessy M.V. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 700 1- Hogg R.S. British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Canada aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/8(2000-09-01), 941-949 0962-9343 9:8<941 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer