caa a22 4500 475847504 CHVBK 20180406123918.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1008917432368 doi (NATIONALLICENCE)springer-10.1023/A:1008917432368 The effect of individually assessed preference weights on the relationship between holistic utilities and nonpreference-based assessment [Elektronische Daten] [Sylvia Jansen, Anne Stiggelbout, Marianne Nooij, Job Kievit] In the assessment of health-related quality of life, nonpreference-based methods usually show only moderate correlations with utility-based measures. One cause may be that patients assign different weights to the various domains of health-related quality of life, for which nonpreference-based methods usually do not allow. Utilities reflect a weighted sum of these domains. The aim of this study is to assess whether the relationship between utility-based methods and nonpreference-based measures improves through the use of individual importance weights for the various domains of health-related quality of life. For this purpose, weights were obtained from 41 early-stage breast cancer patients, both before and during treatment, for seven pre-selected health status attributes representing important domains of health-related quality of life during chemotherapy. The importance weights were combined with the level of functioning on the attributes. These scores were regressed against patients' utilities for their actually experienced health state during chemotherapy, measured by means of a visual analog scale (VAS), a time trade-off (TTO), and a standard gamble (SG). Before weighting, the seven attribute scores were more strongly related to TTO and SG utilities than the nonpreference-based questionnaires. However, when they were combined with the importance weights, only the correlation with the SG utilities improved, and only so with the importance weights obtained before chemotherapy. In this study, assigning individually assessed preference weights to self-reported level of functioning did not result in stronger relationships with utilities. Kluwer Academic Publishers, 2000 Health-related quality of life nationallicence Importance weights nationallicence Multiattribute utility theory nationallicence Utilities nationallicence Jansen Sylvia Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut Stiggelbout Anne Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut Nooij Marianne Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands aut Kievit Job Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut Quality of Life Research Kluwer Academic Publishers 9/5(2000-05-01), 541-557 0962-9343 9:5<541 2000 9 11136 https://doi.org/10.1023/A:1008917432368 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008917432368 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jansen Sylvia Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Stiggelbout Anne Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Nooij Marianne Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Kievit Job Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Quality of Life Research Kluwer Academic Publishers 9/5(2000-05-01), 541-557 0962-9343 9:5<541 2000 9 11136 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer