caa a22 4500 475848098 CHVBK 20180406123920.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00007506 doi (NATIONALLICENCE)springer-10.1007/PL00007506 Autofluorescence imaging in the diagnosis of laryngeal cancer [Elektronische Daten] [M. Žargi, I. Fajdiga, L. Šmid] Differences in autofluorescence (fluorescence without photodynamic drugs) between normal and malignant tissues offer new possibilities in detecting and localizing early laryngeal carcinoma. Autofluorescence imaging was performed using a modified fluorescence endoscopy system from Xillix Technologies (Richmond, Canada). Fluorescence was induced by blue light at 442 nm and captured by an image-intensified camera through a laryngeal telescope. The images were then processed by the system and displayed on a video monitor. Normal tissue appeared green while malignant sites appeared reddish-brown. The autofluorescence imaging technique was compared to standard microlaryngoscopy in 108 patients with laryngeal pathologies (in 74 of whom malignancy was suspected). The acquired reflectance and fluorescence images of each lesion were assessed independently as malignant or not malignant by three ENT specialists who were familiar with the procedure but were not provided with clinical data or histopathological information concerning the lesion. The assessments of pathology were determined from the two imaging modalities and were compared to histopathological findings of the biopsy specimens taken from the lesion. The present study showed that autofluorescence imaging can be a useful complementary method to microlaryngoscopy for detecting and delineating laryngeal malignancies. If in the future, the device can be developed for use in an outpatient office, a significant improvement can be made for the early detection of laryngeal malignancies. Springer-Verlag Berlin Heidelberg, 2000 Key words Laryngeal cancer nationallicence Diagnosis nationallicence Autofluorescence nationallicence Žargi M. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut Fajdiga I. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut Šmid L. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut https://doi.org/10.1007/PL00007506 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00007506 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Žargi M. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut NATIONALLICENCE 700 1- Fajdiga I. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut NATIONALLICENCE 700 1- Šmid L. University Department of Otorhinolaryngology and Cervicofacial Surgery, Zaloška 2, 1525 Ljubljana, Slovenia, SI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer