caa a22 4500 475848160 CHVBK 20180406123920.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004059900208 doi (NATIONALLICENCE)springer-10.1007/s004059900208 Serum levels of vascular endothelial growth factor in patients with head and neck cancer [Elektronische Daten] [F. Riedel, Karl Götte, Joachim Schwalb, Heiner Wirtz, Wolfgang Bergler, Karl Hörmann] Angiogenesis is now considered to be crucial for tumor growth and metastasis. In several tumors, microvascular density has been shown to be correlated with metastasis and aggressiveness. Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen, which is induced by hypoxia and is angiogenic in vivo. VEGF has been identified in a wide variety of malignancies including head and neck squamous cell carcinomas (HNSCC). We investigated the circulating level of VEGF in sera from patients with various head and neck squamous cell carcinomas (n = 71) as well as from healthy normal controls (n = 47). Serum VEGF concentrations were determined as serum immunoreactivity by using a quantitative sandwich enzyme immunoassay technique. For statistical analysis, the Wilcoxon 2-sample test and Kruskal-Wallis test were performed. The majority of the patients with HNSCC were found to have high concentrations of serum VEGF. The levels of VEGF in the sera of patients with cancer ranged from below the detection limit to 937.1 pg/ml (mean, 144.5 pg/ml). In contrast, the VEGF serum levels in 47 healthy individuals ranged from below the detection limit to 168.1 pg/ml (mean, 32.7 pg/ml), VEGF serum concentration being significantly higher in HNSCC patients (P = < 0.001). These findings indicate that a positive angiogenesis regulator such as VEGF might function as an endocrine growth factor, particularly for solid HNSCC tumors and may be a useful marker for clinical monitoring. Springer-Verlag Berlin Heidelberg, 2000 Keywords Vascular endothelial growth factor nationallicence Tumor angiogenesis nationallicence Head and neck squamous cell carcinoma nationallicence Riedel F. Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Götte Karl Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Schwalb Joachim Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Wirtz Heiner Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Bergler Wolfgang Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Hörmann Karl Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut https://doi.org/10.1007/s004059900208 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004059900208 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Riedel F. Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Götte Karl Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Schwalb Joachim Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Wirtz Heiner Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Bergler Wolfgang Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Hörmann Karl Department of Otolaryngology, Head and Neck Surgery, University Hospital of Mannheim, 68135 Mannheim, Germany e-mail: frank.riedel@hno.ma.uni-heidelberg.de, Tel.: +49-621-3832249, Fax: +49-621-3833827, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer