caa a22 4500 475848209 CHVBK 20180406123920.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004059900222 doi (NATIONALLICENCE)springer-10.1007/s004059900222 Initial experience in the treatment of oral leukoplakia with high-dose vitamin A and follow-up 5-aminolevulinic acid induced protoporphyrin IX fluorescence [Elektronische Daten] [A. Leunig, Christian S. Betz, Reinhold Baumgartner, Gerhard Grevers, Wolfgang J. Issing] The aim of photodynamic diagnostics is complete visualization of all neoplastic lesions in a tumorous organ after the application of a tumor-selective photosensitizer. We explored the potential benefit of a combination of retinyl palmitate for the treatment of oral leukoplakias and follow-up diagnosis of malignant tissue by using 5-aminolevulinic acid (5-ALA) as a fluorescence marker. Semiquantitative measurements were performed following the topical application of 5-ALA in six patients. After biopsy and histological evaluation of tissue specimens the patients were treated with escalating doses of retinyl palmitate. After treatment periods ranging from 4 to 8 weeks 5-ALA was again applied for photodetection of persisting fluorescence. In all cases prior to retinyl palmitate treatment a prominent red fluorescence indicated tissue dysplasia. Eight weeks after treatment with retinyl palmitate decreased red fluorescence intensities were found, and repeated histological evaluations showed no persistent signs of dysplastic lesions. Our initial experience shows that high doses of retinyl palmitate can be useful for treating dysplastic lesions in the upper aerodigestive tract and can be monitored with 5-ALA induced protoporphyrin IX fluorescence. Springer-Verlag Berlin Heidelberg, 2000 Keywords Leukoplakia nationallicence Retinyl palmitate treatment nationallicence 5-Aminolevulinic acid induced fluorescence nationallicence Leunig A. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut Betz Christian S. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut Baumgartner Reinhold Laser Research Laboratory, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany, DE aut Grevers Gerhard Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut Issing Wolfgang J. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut https://doi.org/10.1007/s004059900222 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004059900222 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leunig A. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut NATIONALLICENCE 700 1- Betz Christian S. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut NATIONALLICENCE 700 1- Baumgartner Reinhold Laser Research Laboratory, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany, DE aut NATIONALLICENCE 700 1- Grevers Gerhard Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut NATIONALLICENCE 700 1- Issing Wolfgang J. Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany e-mail: Andreas.Leunig@hno.med.uni-muenchen.de, Tel.: +49-89-70951, Fax: +49-89-70958825/8891, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer