caa a22 4500 475848306 CHVBK 20180406123921.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004050000265 doi (NATIONALLICENCE)springer-10.1007/s004050000265 Prognostic significance of argyrophilic nucleolar organizer regions in nasopharyngeal carcinoma [Elektronische Daten] [M. W. Pak, K. F. To, S. F. Leung, C. A. van Hasselt] Increased expression of argyrophilic nucleolar organizer regions (AgNORs) has been identified in certain malignant tumors including nasopharyngeal carcinoma (NPC). However, its prognostic significance in NPC is uncertain and remains to be evaluated. To address this we silver-stained 63 paraffin sections of NPC cases, and examined the correlation between AgNOR count and area, calculated by the CAS 200 image analysis system, and tumor behavior, locoregional control, and survival of patients. The mean AgNOR count and area were 1.62 ± 0.31 and 3.98 ± 11.4 μm2, respectively. The AgNOR area was positively associated with T stage (r = 0.26, P = 0.04). The Mann-Whitney test confirmed no significant difference in AgNOR area and count between patients with different outcomes. Multivariate analysis using the Cox proportional hazard model showed neither AgNOR count nor area to be significant predictors of actuarial survival or disease-free survival. It is concluded that AgNOR does not have an independent and significant prognostic value in NPC. AgNOR expression may be merely a reflection of malignant phenotype as well as cellular activity but not necessarily the ultimate behavior of the tumor. Springer-Verlag Berlin Heidelberg, 2000 Key words Nucleolar organizer region nationallicence Nasopharyngeal carcinoma nationallicence Silver-staining nationallicence Prognosis nationallicence Outcome nationallicence Pak M. W. Division of Otorhinolaryngology, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China Tel.: +85-2-26322628, Fax: +85-2-26466312, CN aut To K. F. Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China, CN aut Leung S. F. Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China, CN aut van Hasselt C. A. Division of Otorhinolaryngology, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China Tel.: +85-2-26322628, Fax: +85-2-26466312, CN aut https://doi.org/10.1007/s004050000265 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050000265 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pak M. W. Division of Otorhinolaryngology, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China Tel.: +85-2-26322628, Fax: +85-2-26466312, CN aut NATIONALLICENCE 700 1- To K. F. Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China, CN aut NATIONALLICENCE 700 1- Leung S. F. Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China, CN aut NATIONALLICENCE 700 1- van Hasselt C. A. Division of Otorhinolaryngology, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China Tel.: +85-2-26322628, Fax: +85-2-26466312, CN aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer