caa a22 4500 475848330 CHVBK 20180406123921.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004050000277 doi (NATIONALLICENCE)springer-10.1007/s004050000277 Treatment of neck nodes after induction chemotherapy in patients with primary advanced tumours [Elektronische Daten] [X. León, M. Quer, C. Orús, E. de Dios, K. Recher] Responsiveness of neck nodes to induction chemotherapy often differs from that of the primary tumour. We have conducted a retrospective study to evaluate the results of treating the neck in a cohort of 350 patients with locally advanced (T3-4) head and neck carcinomas treated with radiation therapy at the primary location of the tumour after induction chemotherapy. One hundred and thirty-nine patients (40%) did not have neck nodes on diagnosis (N0). The treatment of the neck included surgery in 65 patients. Neck dissections were carried out before radiotherapy in 37 patients and after radiotherapy in 28 patients. The frequency of neck treatment failure was 24%. There was a tendency to better neck control when treatment included neck dissection, independently of the neck stage or response to chemotherapy. This tendency was statistically significant in patients with an advanced regional tumour (N2-3) who did not achieve a complete regional response after chemotherapy. In a multivariate analysis the variables that were related to the regional failure were the relapse of the tumour at the primary site, the neck stage (N), the type of treatment used in the neck, and the grade of regional response after induction chemotherapy. Our results lead us to suggest that after induction chemotherapy neck surgery is advisable in all cases with advanced regional disease (N2-3), independently of the grade of response achieved after induction chemotherapy, and is also advisable in N1 patients in whom induction chemotherapy does not achieve a complete response. Springer-Verlag Berlin Heidelberg, 2000 Key words Metastatic neck nodes nationallicence Induction ¶chemotherapy nationallicence Regional treatment nationallicence Head and neck ¶carcinoma nationallicence León X. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut Quer M. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut Orús C. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut de Dios E. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut Recher K. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut https://doi.org/10.1007/s004050000277 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050000277 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- León X. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut NATIONALLICENCE 700 1- Quer M. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut NATIONALLICENCE 700 1- Orús C. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut NATIONALLICENCE 700 1- de Dios E. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut NATIONALLICENCE 700 1- Recher K. Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Avda San Antoni M. Claret 167, 08025 Barcelona, Spain e-mail: 4145@hsp.santpau.es, Tel.: +34-93-2919159, Fax: +34-93-2919277, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer