caa a22 4500 475848357 CHVBK 20180406123921.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004050000283 doi (NATIONALLICENCE)springer-10.1007/s004050000283 Detection of particles within the nasal airways during respiration [Elektronische Daten] [T. Keck, R. Leiacker, M. Klotz, J. Lindemann, H. Riechelmann, G. Rettinger] This study introduces a new experimental set-up for particle detection within the nasal airways and describes intranasal deposition of particles at various regions of the nasal cavity and the nasopharynx. During respiration of an aerosol of starch particles the nondeposited particles in the air were detected in 11 volunteers by a transnasally placed suction probe at numerous sites of the nasal cavity and nasopharynx. Another, identical suction probe measured the initial number of inhaled particles at the nostril. The two suction probes were connected to two identical laser particle counters and allowed calculation of particle deposition. Particles 1-3 μm in size were deposited to about 60% within the entire nasal cavity, whereas most of the particles 4-30 μm in size were deposited within the entire nasal cavity. Between 80% and 90% of the particles retained in the nasal cavity were deposited at the anterior nasal segment. Studies on deposition of various drugs within the nasal cavity using this experimental set-up are conceivable. Springer-Verlag Berlin Heidelberg, 2000 Key words Particle deposition nationallicence Intranasal measurement nationallicence Aerosol nationallicence Regional intranasal particle mapping nationallicence Keck T. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut Leiacker R. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut Klotz M. Klotz-Lasertechnologien in der Medizin-, Meß- und Umwelttechnik, Bad Liebenzell, Germany, DE aut Lindemann J. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut Riechelmann H. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut Rettinger G. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut https://doi.org/10.1007/s004050000283 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050000283 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Keck T. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut NATIONALLICENCE 700 1- Leiacker R. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut NATIONALLICENCE 700 1- Klotz M. Klotz-Lasertechnologien in der Medizin-, Meß- und Umwelttechnik, Bad Liebenzell, Germany, DE aut NATIONALLICENCE 700 1- Lindemann J. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut NATIONALLICENCE 700 1- Riechelmann H. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut NATIONALLICENCE 700 1- Rettinger G. Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer