caa a22 4500 475848527 CHVBK 20180406123921.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004050000231 doi (NATIONALLICENCE)springer-10.1007/s004050000231 Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas [Elektronische Daten] [A. Ozdek, Sarp Sarac, M. Umut Akyol, O. Faruk Unal, Arzu Sungur] Lymph node metastasis appears to be the most important factor determining survival in patients with squamous cell carcinoma of the larynx. Supraglottic laryngeal carcinomas have a known tendency to metastasize to cervical lymph nodes because of the extensive lymphatic network present. This retrospective cohort study was conducted to define possible histopathological parameters affecting cervical lymph node metastasis and then using these parameters to create a scale to predict occult lymph node metastasis in supraglottic squamous cell carcinoma. The pathological slides of 61 operated patients were reevaluated for tumor grade, lymphatic-vascular invasion, invasion pattern of tumor margins, perineural invasion and lymphocytic infiltration. Grade (P < 0.001), lymphatic-vascular invasion (P < 0.001) and tumor margins (P = 0.007) were found to be closely associated with neck metastasis. To define the risk factors for occult metastasis, a grading scale was created by using grade (G), lymphatic-vascular invasion (L) and tumor margin (M) findings of patients. None of the patients with a GLM value of zero developed occult metastasis. On the other hand occult metastasis was found in 58.8% of N0 patients with a GLM value that was more than zero. These findings indicate that patients with high-grade tumors having infiltrating borders and lymphatic-vascular invasion have a high risk for occult metastasis so that elective treatment of the neck either by neck dissection or radiotherapy should be added to therapy. Serial sections of specimens are needed to avoid missing metastatic loci of disease. Springer-Verlag Berlin Heidelberg, 2000 Key words Laryngeal neoplasms nationallicence Epidermoid nationallicence carcinoma nationallicence Lymph node metastasis nationallicence Histopathology nationallicence Ozdek A. Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut Sarac Sarp Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut Akyol M. Umut Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut Unal O. Faruk Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut Sungur Arzu Department of Pathology, Hacettepe University School of Medicine Ankara, Turkey, TR aut https://doi.org/10.1007/s004050000231 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050000231 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ozdek A. Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Sarac Sarp Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Akyol M. Umut Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Unal O. Faruk Department of Otolaryngology, Hacettepe University School of Medicine Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Sungur Arzu Department of Pathology, Hacettepe University School of Medicine Ankara, Turkey, TR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer