caa a22 4500 47584856X CHVBK 20180406123921.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004050050208 doi (NATIONALLICENCE)springer-10.1007/s004050050208 The effect of impulse noise exposure on distortion product otoacoustic emissions in the awake guinea pig [Elektronische Daten] [E. Emmerich, F. Richter, W. Meißner, H. -G. Dieroff] Distortion product otoacoustic emissions (DPOAE) are a sensitive detector of outer hair cell (OHC) function and were monitored in awake guinea pigs before and after impulse noise damaging the cochlea (peak intensity 153 dB SPL, rise time < 0.1 ms). Animals had stable DPOAE levels before noise exposure. In the first hours after noise exposure DPOAE levels were reduced significantly. Three different patterns of recovery of DPOAE were seen in the post-exposure period: restitution exceeding controls, partial recovery and no recovery. In general, DPOAE levels declined and types of recovery closely corresponded to changes in amplitudes of cochlear microphonics after noise exposure. These data suggest that the monitoring of DPOAE is a suitable method for diagnosing impaired OHC function. Springer-Verlag Berlin Heidelberg, 2000 Key words Distortion product nationallicence Otoacoustic emissions nationallicence Outer hair cells nationallicence Impulse noise exposure nationallicence Hearing loss nationallicence Guinea pig studies nationallicence Emmerich E. Department of Physiology I, Medical Faculty of the Friedrich Schiller University of Jena, Teichgraben 8, 07743 Jena, Germany e-mail: eemm@mti-n.uni-jena.de, Tel.: +49 3641 9 388 27, Fax: +49 3641 9 388 12, DE aut Richter F. Department of Physiology I, Medical Faculty of the Friedrich Schiller University of Jena, Teichgraben 8, 07743 Jena, Germany e-mail: eemm@mti-n.uni-jena.de, Tel.: +49 3641 9 388 27, Fax: +49 3641 9 388 12, DE aut Meißner W. Department of Audiology, Medical Faculty of the Friedrich Schiller University of Jena, Lessingstrasse 4, 07743 Jena, Germany, DE aut Dieroff H. -G Department of Audiology, Medical Faculty of the Friedrich Schiller University of Jena, Lessingstrasse 4, 07743 Jena, Germany, DE aut https://doi.org/10.1007/s004050050208 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050050208 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Emmerich E. Department of Physiology I, Medical Faculty of the Friedrich Schiller University of Jena, Teichgraben 8, 07743 Jena, Germany e-mail: eemm@mti-n.uni-jena.de, Tel.: +49 3641 9 388 27, Fax: +49 3641 9 388 12, DE aut NATIONALLICENCE 700 1- Richter F. Department of Physiology I, Medical Faculty of the Friedrich Schiller University of Jena, Teichgraben 8, 07743 Jena, Germany e-mail: eemm@mti-n.uni-jena.de, Tel.: +49 3641 9 388 27, Fax: +49 3641 9 388 12, DE aut NATIONALLICENCE 700 1- Meißner W. Department of Audiology, Medical Faculty of the Friedrich Schiller University of Jena, Lessingstrasse 4, 07743 Jena, Germany, DE aut NATIONALLICENCE 700 1- Dieroff H. -G Department of Audiology, Medical Faculty of the Friedrich Schiller University of Jena, Lessingstrasse 4, 07743 Jena, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer