caa a22 4500 475848594 CHVBK 20180406123922.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004050050210 doi (NATIONALLICENCE)springer-10.1007/s004050050210 HLA patterns in patients with nasal polyposis [Elektronische Daten] [W. Luxenberger, U. Posch, A. Berghold, T. Hofmann, D. Lang-Loidolt] The etiology of nasal polyposis is still unknown, although risk factors include Aspirin intolerance, asthma, cystic fibrosis and primary ciliary dyskinesia. We studied frequencies of HLA A, B, DR and DQ in patients with nasal polyposis in order to determine a possible genetic component in the multifactorial pathogenesis of nasal polyps. Previous work has suggested an association of HLA-A1B8 with nasal polyposis and Aspirin intolerance. We investigated 89 patients with nasal polyposis, 11 of whom had Aspirin-intolerance, 19 asthma and 22 allergies to inhalation allergens. HLA patterns of these patients were compared to the ones of 1,070 healthy controls. No significant association of HLA-A1B8 was found with nasal polyps in the Aspirin-sensitive subgroup of our patients, but a significant association was seen with HLA-A74 and nasal polyposis. Springer-Verlag Berlin Heidelberg, 2000 Key words Nasal polyps nationallicence Pathogenesis nationallicence HLA system nationallicence Luxenberger W. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut Posch U. Department of Transfusion Medicine and Immunology-Hematology, University of Graz, Graz, Austria, AT aut Berghold A. Institute of Medical Information, Statistics and Documentation, University of Graz, Graz, Austria, AT aut Hofmann T. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut Lang-Loidolt D. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut https://doi.org/10.1007/s004050050210 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050050210 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luxenberger W. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut NATIONALLICENCE 700 1- Posch U. Department of Transfusion Medicine and Immunology-Hematology, University of Graz, Graz, Austria, AT aut NATIONALLICENCE 700 1- Berghold A. Institute of Medical Information, Statistics and Documentation, University of Graz, Graz, Austria, AT aut NATIONALLICENCE 700 1- Hofmann T. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut NATIONALLICENCE 700 1- Lang-Loidolt D. ENT University Hospital Graz, Auenbruggerplatz 20, 8036 Graz, Austria Tel.: +43 316 385 2580, Fax: +43 316 385 3425, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer