caa a22 4500 475848667 CHVBK 20180406123922.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004050050214 doi (NATIONALLICENCE)springer-10.1007/s004050050214 A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue [Elektronische Daten] [S. Elgün, K. Güney, M. Tuncer, I. H. Gökhun] Since arginase has been found to be an arginine-depleting and nitric oxide synthase-regulating enzyme, the present study was devised to examine hypertrophied and infected tonsil and adenoid arginase activity in relation to a metabolic arginase-nitric oxide pathway and its association with disease processes. Tissues were taken from 32 children undergoing adenotonsillectomy. There was a statistically significant difference between the two tissue enzyme activities, with tonsillar arginase activity being higher than the corresponding adenoidal tissue (P < 0.005). This suggests a potential role for tissue arginase activity as an outcome module and a contributing factor in chronic recurrent infection and hypertrophy of tonsillar and adenoidal tissues. Springer-Verlag Berlin Heidelberg, 2000 Key words Arginase nationallicence Tonsillitis nationallicence Tonsillar and ¶adenoidal hypertrophy nationallicence Elgün S. Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey, TR aut Güney K. Ankara Numune Hospital, ENT Clinic, Ankara, Turkey, TR aut Tuncer M. Ankara Numune Hospital, ENT Clinic, Ankara, Turkey, TR aut Gökhun I. H. Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey, TR aut https://doi.org/10.1007/s004050050214 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050050214 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elgün S. Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Güney K. Ankara Numune Hospital, ENT Clinic, Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Tuncer M. Ankara Numune Hospital, ENT Clinic, Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Gökhun I. H. Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey, TR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer