caa a22 4500 475848721 CHVBK 20180406123922.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004050000271 doi (NATIONALLICENCE)springer-10.1007/s004050000271 Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease [Elektronische Daten] [G. Bachmann, Gerhard Hommel, Olaf Michel] In a prospective, randomized, controlled, double-blind trial we compared the effectiveness of endonasal irrigations with Ems salt solution to that with sodium chloride solution in the treatment of adult patients with chronic paranasal sinus disease. Subjects (n = 40) were randomly allocated to treatment either with isotonic Ems salt solution or with isotonic sodium chloride solution. The treatment consisted of endonasal irrigation twice daily and additional nasal spray as required. Nasal endoscopy, plain radiography of the paranasal sinuses, olfactometry, anterior rhinomanometry, and a saccharin-clearance test were carried out on days 1 and 7. Patients recorded rating scales of general discomfort, nasal airway obstruction, agreeableness of the irrigation, duration of improved nasal resistance after each irrigation, and the amount of additional nasal spray in a diary. Nasal air flow was not improved significantly. Subjective complaints, endonasal endoscopy, and radiography results revealed a significant improvement in both groups (P = 0.0001). In comparison, the two groups were not significantly different in outcome. Endonasal irrigations with salt solutions are effective in the treatment of chronic sinusitis, and a significant difference between Ems salt and sodium chloride was not observed. Springer-Verlag Berlin Heidelberg, 2000 Keywords Paranasal sinus diseases nationallicence Mucociliary nationallicence clearance nationallicence Nasal irrigation fluid nationallicence Nasal obstruction nationallicence Bachmann G. Otorhinolaryngological Clinic, Cologne University, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany e-mail: gregor.bachmann@uni-koeln.de, Tel.: +49-221-4784760, Fax: +49-221-4784793, DE aut Hommel Gerhard Institute of Statistics and Documentation, Mainz University, Mainz, Germany, DE aut Michel Olaf Otorhinolaryngological Clinic, Cologne University, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany e-mail: gregor.bachmann@uni-koeln.de, Tel.: +49-221-4784760, Fax: +49-221-4784793, DE aut https://doi.org/10.1007/s004050000271 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050000271 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bachmann G. Otorhinolaryngological Clinic, Cologne University, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany e-mail: gregor.bachmann@uni-koeln.de, Tel.: +49-221-4784760, Fax: +49-221-4784793, DE aut NATIONALLICENCE 700 1- Hommel Gerhard Institute of Statistics and Documentation, Mainz University, Mainz, Germany, DE aut NATIONALLICENCE 700 1- Michel Olaf Otorhinolaryngological Clinic, Cologne University, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany e-mail: gregor.bachmann@uni-koeln.de, Tel.: +49-221-4784760, Fax: +49-221-4784793, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer