caa a22 4500 475849175 CHVBK 20180406123923.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004050050236 doi (NATIONALLICENCE)springer-10.1007/s004050050236 Current advances in the basic research and clinical management of juvenile-onset recurrent respiratory papillomatosis [Elektronische Daten] [W. F. Bergler, K. Götte] Juvenile-onset recurrent respiratory papillomatosis is a relatively uncommon disease that presents clinically with symptoms ranging from hoarseness to severe dyspnea. Human papilloma viruses type 6 and 11 are important in the etiology of the papillomata and are most probably transmitted from mother to child during childbirth. Although spontaneous remission is frequent, a rare fatal course because of pulmonary spread or malignant transformation has occurred. CO2 laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid α-interferon are the most common treatment modalities at present. However, several other treatment modalities have been tried with varying success. Recent advances in basic research and different therapeutic approaches are reviewed. Springer-Verlag Berlin Heidelberg, 2000 Key words Recurrent respiratory papillomatosis nationallicence Pediatric laryngeal disease nationallicence Human papilloma virus nationallicence Bergler W. F. Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, 68135 Mannheim, Germany e-mail: wolfgang.bergler@hno.ma.uni-heidelberg.de, Tel.: +49-621-3833965, Fax: +49-621-3833827, DE aut Götte K. Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, 68135 Mannheim, Germany e-mail: wolfgang.bergler@hno.ma.uni-heidelberg.de, Tel.: +49-621-3833965, Fax: +49-621-3833827, DE aut https://doi.org/10.1007/s004050050236 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050050236 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergler W. F. Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, 68135 Mannheim, Germany e-mail: wolfgang.bergler@hno.ma.uni-heidelberg.de, Tel.: +49-621-3833965, Fax: +49-621-3833827, DE aut NATIONALLICENCE 700 1- Götte K. Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, 68135 Mannheim, Germany e-mail: wolfgang.bergler@hno.ma.uni-heidelberg.de, Tel.: +49-621-3833965, Fax: +49-621-3833827, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer