caa a22 4500 475849191 CHVBK 20180406123923.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004050050235 doi (NATIONALLICENCE)springer-10.1007/s004050050235 Malignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma [Elektronische Daten] [L. Resta, A. Pennella, M. G. Fiore, M. A. Botticella] A few cases of malignant fibrous histiocytoma (MFH) of the larynx have been reported to date. All ages may be affected, but the tumor is more prevalent in the sixth and seventh decade of life. We describe a case of MFH in a 71-year-old Italian man who 8 years before underwent a right cordectomy and radiotherapy for squamous cell carcinoma. Recurrent tumor was found to be MFH. The clinico-pathological features of this tumor are presented and the possible relationship between radiotherapy and MFH discussed. The neoplasm was characterized by spindle-shaped atypical cells arranged in a diffuse storiform pattern. Mitoses were prominent, numerous, and often atypical. Immunohistochemically, neoplastic cells were strongly positive for vimentin and α1-antichymotrypsin but were negative for cytokeratins and S-100 protein. These findings confirmed the diagnosis and excluded possible sarcomatoid carcinoma, inflammatory pseudotumor, and a new carcinosarcoma. The risk of sarcoma after radiotherapy for squamous cell carcinoma in the larynx is very low when considering the frequent use of radiotherapy, but long follow-ups are required. Springer-Verlag Berlin Heidelberg, 2000 Key words Laryngeal neoplasms nationallicence Malignant ¶histiocytoma nationallicence Radiotherapy nationallicence Resta L. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut Pennella A. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut Fiore M. G. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut Botticella M. A. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut https://doi.org/10.1007/s004050050235 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004050050235 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Resta L. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut NATIONALLICENCE 700 1- Pennella A. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut NATIONALLICENCE 700 1- Fiore M. G. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut NATIONALLICENCE 700 1- Botticella M. A. Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.it, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer