caa a22 4500 475849221 CHVBK 20180406123923.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/PL00007510 doi (NATIONALLICENCE)springer-10.1007/PL00007510 Heparin-induced extracorporal low-density-lipoprotein precipitation (H. E. L. P.) to improve the recovery of hearing in patients with sudden idiopathic hearing loss [Elektronische Daten] [M. Suckfüll, C. Wimmer, B. Jäger, K. Schorn, J. Thiery] The pathogenesis of sudden hearing loss (SHL) is still not well understood. Possible causes include increased blood viscosity, microthrombosis or altered blood flow. Hypercholesterolemia, hyperfibrinogenemia and increased platelet aggregation are frequently observed in patients with SHL. The aim of this study was to investigate whether drastic lowering of plasma cholesterol and fibrinogen by selective extracorporal apheresis could have a beneficial effect on hearing recovery in these patients. Seven patients with SHL were treated with an extracorporal procedure removing fibrinogen and cholesterol from plasma. Six of the seven patients showed an immediate improvement in auditory thresholds following a single treatment of heparin-induced low-density lipoprotein precipitation. These findings indicate for the first time that acute and drastic removal of plasma fibrinogen and low-density lipoproteins may be an effective clinical method for the treatment of patients with SHL. Springer-Verlag Berlin Heidelberg, 2000 Key words Sudden hearing loss nationallicence Cholesterol nationallicence Fibrinogen nationallicence Heparin-induced low-density nationallicence Lipoprotein ¶precipitation nationallicence Suckfüll M. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut Wimmer C. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut Jäger B. Institute of Clinical Chemistry, University Hospital Großhadern, Ludwig Maximilians University of Munich, Munich, Germany, DE aut Schorn K. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut Thiery J. Institute of Clinical Chemistry, University Hospital Großhadern, Ludwig Maximilians University of Munich, Munich, Germany, DE aut https://doi.org/10.1007/PL00007510 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00007510 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suckfüll M. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut NATIONALLICENCE 700 1- Wimmer C. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut NATIONALLICENCE 700 1- Jäger B. Institute of Clinical Chemistry, University Hospital Großhadern, Ludwig Maximilians University of Munich, Munich, Germany, DE aut NATIONALLICENCE 700 1- Schorn K. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Großhadern, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 München, Germany, DE aut NATIONALLICENCE 700 1- Thiery J. Institute of Clinical Chemistry, University Hospital Großhadern, Ludwig Maximilians University of Munich, Munich, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer