caa a22 4500 477034454 CHVBK 20180405111301.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF00420281 doi (NATIONALLICENCE)springer-10.1007/BF00420281 Network connectivity changes through activity-dependent neurite outgrowth [Elektronische Daten] [A. van Ooyen, K. Pakdaman, A. Houweling, J. van Pelt, J. Vibert] There is experimental evidence that neuronal electrical activity directly influences neurite outgrowth during the development of the nervous system. Using model studies, Van Ooyen and Van Pelt extensively investigated the effect of this phenomenon upon network development and architecture. Their studies are based on the experimental observations that there is an optimal range of electrical activity at which neurite outgrowth takes place. In their model, neurite growth occurs if the activity level of the neuron is below a certain threshold, otherwise the neurite retracts. We extend their results to include a more complete description of the relationship between electrical activity and neurite outgrowth. This takes into account the experimental observation that outgrowth ceases not only when neuronal activity is too high, but also when it is below a certain threshold. The modified model displays a wider range of behaviours during network development. In some cases, for example, growth is only transient and is followed by a total loss of connections in the network. As a consequence of the larger spectrum of possible behaviours, the mechanisms for control of network formation, by the network's internal dynamics as well as by external inputs, are also increased. Kluwer Academic Publishers, 1996 neurite outgrowth nationallicence network formation nationallicence electrical activity nationallicence van Ooyen A. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut Pakdaman K. B3E, INSERM U444, ISARS, Faculté de Médecine Saint-Antoine, UPMC, 27, rue Chaligny, 75571, Paris Cedex 12, France aut Houweling A. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut van Pelt J. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut Vibert J. B3E, INSERM U444, ISARS, Faculté de Médecine Saint-Antoine, UPMC, 27, rue Chaligny, 75571, Paris Cedex 12, France aut Neural Processing Letters Kluwer Academic Publishers; http://www.wkap.nl 3/3(1996-08-01), 123-130 1370-4621 3:3<123 1996 3 11063 https://doi.org/10.1007/BF00420281 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00420281 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Ooyen A. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Pakdaman K. B3E, INSERM U444, ISARS, Faculté de Médecine Saint-Antoine, UPMC, 27, rue Chaligny, 75571, Paris Cedex 12, France aut NATIONALLICENCE 700 1- Houweling A. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Pelt J. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Vibert J. B3E, INSERM U444, ISARS, Faculté de Médecine Saint-Antoine, UPMC, 27, rue Chaligny, 75571, Paris Cedex 12, France aut NATIONALLICENCE 773 0- Neural Processing Letters Kluwer Academic Publishers; http://www.wkap.nl 3/3(1996-08-01), 123-130 1370-4621 3:3<123 1996 3 11063 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer