caa a22 4500 477034543 CHVBK 20180405111301.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900001 doi (NATIONALLICENCE)springer-10.1007/s002689900001 Hypercoagulability following Multiple Trauma [Elektronische Daten] [Daniel T. Engelman, Sheryl G.A. Gabram, Lisa Allen, Gordon E. Ens, Lenworth M. Jacobs] Abstract. We sought evidence of hypercoagulability in 59 seriously injured trauma patients. An extended coagulation profile (consisting of tissue plasminogen activator antigen concentration, plasminogen activator inhibitor, serum antithrombin III, protein C antigen, functional protein C, protein S antigen, D-dimer, and prothrombin fragment 1.2) was compared to control values. Laboratory evidence of hypercoagulability was seen in 85% (: n = 50) of the patients. Patients with an Injury Severity Score (ISS) ≥ 16 ( n = 36) had significantly elevated levels of D-dimer and decreased levels of functional protein C compared to patients with an ISS ≤ 15 ( n = 23). Functional protein C had a negative correlation ( r =−0.44; p < 0.001) with the ISS. A hypercoagulable state exists immediately following severe trauma. Greater injury severity may increase this hypercoagulable state. Decreased levels of functional protein C best correlated with increased injury severity. 1996 by the Société Internationale de Chir, ugie Engelman Daniel T. Surgical Research Center, University of Connecticut School of Medicine, Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1110, U.S.A., US aut Gabram Sheryl G.A. Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut Allen Lisa Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut Ens Gordon E. Colorado Coagulation Consultants, Inc., 820 Clermont St., Denver, Colorado 80220, U.S.A., US aut Jacobs Lenworth M. Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut https://doi.org/10.1007/s002689900001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Engelman Daniel T. Surgical Research Center, University of Connecticut School of Medicine, Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1110, U.S.A., US aut NATIONALLICENCE 700 1- Gabram Sheryl G.A. Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut NATIONALLICENCE 700 1- Allen Lisa Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut NATIONALLICENCE 700 1- Ens Gordon E. Colorado Coagulation Consultants, Inc., 820 Clermont St., Denver, Colorado 80220, U.S.A., US aut NATIONALLICENCE 700 1- Jacobs Lenworth M. Department of Surgery, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer