caa a22 4500 477034608 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900006 doi (NATIONALLICENCE)springer-10.1007/s002689900006 Intramural Metastases from Thoracic Esophageal Cancer: Local Indicators of Advanced Disease [Elektronische Daten] [Tadashi Nishimaki, Tsutomu Suzuki, Yoichi Tanaka, Kikuo Aizawa, Katsuyoshi Hatakeyama, Terukazu Muto] Abstract. The patterns of tumor spread and long-term survival of patients with (: n = 54) and without ( n = 270) intramural metastasis from esophageal cancer were investigated after either extended radical ( n = 155) or less radical ( n = 169) esophagectomy. The purpose was to evaluate whether extended radical esophagectomy has an impact on the long-term survival of patients with intramural metastases from the disease. The patients with intramural metastasis had significantly larger primary tumors ( p < 0.01) and more frequent T4 tumors ( p < 0.001), stage IV disease ( p < 0.05), lymphatic invasion ( p < 0.05), and lymph node metastasis ( p < 0.01) than did those without intramural metastasis. The survival rates of patients with intramural metastases were significantly worse than those of patients without intramural metastases after resection ( p < 0.001). No patient with intramural metastases survived more than 4 years after either extended or less radical esophagectomy, and there was no significant difference between the two survival curves. Therefore intramural metastases should be considered local indicators of advanced esophageal cancer, and radical esophagectomy may not be indicated for patients with intramural metastasis from the disease. 1996 by the Société Internationale de Chir, ugie Nishimaki Tadashi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Suzuki Tsutomu First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Tanaka Yoichi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Aizawa Kikuo First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Hatakeyama Katsuyoshi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Muto Terukazu Niigata University, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut https://doi.org/10.1007/s002689900006 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900006 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishimaki Tadashi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut NATIONALLICENCE 700 1- Suzuki Tsutomu First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut NATIONALLICENCE 700 1- Tanaka Yoichi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut NATIONALLICENCE 700 1- Aizawa Kikuo First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut NATIONALLICENCE 700 1- Hatakeyama Katsuyoshi First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut NATIONALLICENCE 700 1- Muto Terukazu Niigata University, Asahimachi-dori 1-757, Niigata 951, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer