caa a22 4500 477034667 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900016 doi (NATIONALLICENCE)springer-10.1007/s002689900016 Optimal Surgery for Papillary Thyroid Carcinoma [Elektronische Daten] [Robert Udelsman, Edward Lakatos, Paul Ladenson] Abstract. There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to design a randomized prospective trial comparing the endpoints of complications, recurrence, and cause-specific mortality. A complication comparison trial is prohibitive owing to the large population required—approximately 12,000 randomized patients. A recurrence trial appears feasible based on sample size: approximately 360 to 800 patients with a 6 to 10-year follow-up. However, recurrence detection would be severely compromised in the lobectomy arm, and a unilateral lag-time bias would occur. A cause-specific mortality trial proves to be the least objectionable, although a large sample size (: n = 3100) would be required. Such a trial is critically dependent on the ability to select an appropriate endpoint. A cause-specific mortality trial proves to be the most objective and statistically valid endpoint. 1996 by the Société Internationale de Chir, ugie Udelsman Robert Division of Endocrine and Oncologic Surgery, The Johns Hopkins University School of Medicine and The Johns Hopkins Thyroid Tumor Center, Baltimore, Maryland 21287, U.S.A., US aut Lakatos Edward Department of Statistics, G.D. Searle & Company, Skokie, Illinois 60077, U.S.A., US aut Ladenson Paul Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine and The Johns Hopkins Thyroid Tumor Center, Baltimore, Maryland 21287, U.S.A., US aut https://doi.org/10.1007/s002689900016 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900016 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Udelsman Robert Division of Endocrine and Oncologic Surgery, The Johns Hopkins University School of Medicine and The Johns Hopkins Thyroid Tumor Center, Baltimore, Maryland 21287, U.S.A., US aut NATIONALLICENCE 700 1- Lakatos Edward Department of Statistics, G.D. Searle & Company, Skokie, Illinois 60077, U.S.A., US aut NATIONALLICENCE 700 1- Ladenson Paul Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine and The Johns Hopkins Thyroid Tumor Center, Baltimore, Maryland 21287, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer