caa a22 4500 477034683 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900005 doi (NATIONALLICENCE)springer-10.1007/s002689900005 Clinical Significance of DNA Ploidy Pattern in Stage III Gastric Cancer [Elektronische Daten] [Masaru Sakusabe, Masashi Kodama, Yasuhiko Sato, Toshiki Kikuchi, Kenji Koyama] Abstract. Nuclear DNA contents from stage III gastric cancers of 216 patients undergoing curative resection from 1972 to 1987 were measured by flow cytometry using paraffin-embedded materials. To determine the clinical significance of the DNA ploidy pattern, the correlation between it and conventional clinicopathologic findings was studied and a prognostic factor for gastric cancer was investigated by both univariate and multivariate analysis. Survivals were compared for diploidy and aneuploidy patterns in subclasses of stage III gastric cancer as well. The grade of each clinicopathologic factor showed no differences between diploidy and aneuploidy patients. The multivariate analysis revealed that the: p value and Hazard ratio of the DNA ploidy patterns were 0.001 and 2.099, respectively. Consequently, it was a valuable independent prognostic factor that could be used in addition to lymph node metastasis and depth of invasion. For the most advanced subclass of stage III gastric cancer the 5-year survival rate of patients with a diploid tumor was significantly higher than that for those with aneuploid tumor. No difference was observed for the other subclasses. These results indicate that the DNA ploidy pattern is a valuable independent prognostic factor for gastric cancer, and that it is more useful for evaluating the prognosis of patients with more advanced lesions undergoing "curative resection.” 1996 by the Société Internationale de Chir, ugie Sakusabe Masaru Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut Kodama Masashi Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut Sato Yasuhiko Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut Kikuchi Toshiki Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut Koyama Kenji Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut https://doi.org/10.1007/s002689900005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakusabe Masaru Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut NATIONALLICENCE 700 1- Kodama Masashi Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut NATIONALLICENCE 700 1- Sato Yasuhiko Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut NATIONALLICENCE 700 1- Kikuchi Toshiki Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut NATIONALLICENCE 700 1- Koyama Kenji Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer