caa a22 4500 477034705 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900017 doi (NATIONALLICENCE)springer-10.1007/s002689900017 Papillary Thyroid Carcinoma in Mexican Patients: Clinical Aspects and Prognostic Factors [Elektronische Daten] [Miguel F. Herrera, Carlos M. López-Graniel, Jorge Saldaña, Armando Gamboa-Domínguez, Yvonne Richaud-Patín, Florencia Vargas-Vorackova, Arturo Angeles-Angeles, Luis Llorente, Cecilia Castillo, Bernardo Pérez, Raúl Rivera, Ofelia González, Juan Rull] Abstract. The present study characterizes papillary thyroid carcinoma (PTC) in a Mexican patient sample and evaluates potential prognostic factors for recurrence. Clinical records of 229 patients with PTC were analyzed. Surgical specimens were rereviewed and DNA ploidy determined. Cox logistic regression was used to explore prognostic factors. Mean age ± SD of the patients was 42 ± 16 years, with a male/female ratio of 24:205. A thyroid mass was the initial manifestation in 99%. Extrathyroid invasion occurred in 45% and nodal metastases in 38%. Mean size ± SD of the tumors was 3 ± 2 cm. By flow cytometry 88% of the tumors were DNA euploid and 12% aneuploid. Complete tumor resection was achieved in 83% with an operative mortality of 0.4%. Postoperative hormone suppression was administered in 65% and remnant 131 I thyroid ablation in 84%. The 10-year recurrence-free survival was 85%. In the group of patients with tumors totally removed and without distant metastases, none of the 14 evaluated variables demonstrated statistical significance as an independent prognostic factor for recurrence. However, the group of patients in whom a combination of the following factors was present—age ≥ 40 years, tumor size ≥ 3 cm, local invasion, and lymph node metastases—showed a higher incidence of tumor recurrence. : 1996 by the Société Internationale de Chir, ugie Herrera Miguel F. Department of Surgery, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut López-Graniel Carlos M. Department of Surgery, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Saldaña Jorge Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Gamboa-Domínguez Armando Department of Pathology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Richaud-Patín Yvonne Department of Immunology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Vargas-Vorackova Florencia Department of Gastroenterology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Angeles-Angeles Arturo Department of Pathology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Llorente Luis Department of Immunology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Castillo Cecilia Department of Social Work, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Pérez Bernardo Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Rivera Raúl Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut González Ofelia Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Rull Juan Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut https://doi.org/10.1007/s002689900017 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herrera Miguel F. Department of Surgery, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- López-Graniel Carlos M. Department of Surgery, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Saldaña Jorge Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Gamboa-Domínguez Armando Department of Pathology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Richaud-Patín Yvonne Department of Immunology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Vargas-Vorackova Florencia Department of Gastroenterology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Angeles-Angeles Arturo Department of Pathology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Llorente Luis Department of Immunology, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Castillo Cecilia Department of Social Work, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Pérez Bernardo Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Rivera Raúl Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- González Ofelia Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut NATIONALLICENCE 700 1- Rull Juan Departments of Endocrinology/Nuclear Medicine/Thyroid Clinic, Instituto Nacional de la Nutrición, Vasco de Quiroga 15, Tlalpan 14000, Mexico, MX aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer