caa a22 4500 477034721 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/s002689900018 doi (NATIONALLICENCE)springer-10.1007/s002689900018 Stromal Fibroblasts Adjacent to Invasive Thyroid Tumors: Expression of Gelatinase A But Not Stromelysin 3 mRNA [Elektronische Daten] [Jan Zedenius, Mona Ståhle-Bäckdahl, Ulla Enberg, Lars Grimelius, Catharina Larsson, Göran Wallin, Martin Bäckdahl] Abstract. Thyroid tumors vary widely in biologic behavior; they range from benign adenomas to rapidly growing anaplastic carcinomas. Among thyroid neoplasms, the follicular tumor is especially suited as a model for studies of tumor cell invasion; the distinction between adenomas and carcinomas relies mainly on the presence of capsular and vascular invasion. Matrix metalloproteinases play an important role in tumor cell invasion, as they are able to degrade basement membrane and extracellular matrix components. Twenty-nine thyroid tumors of varying type and aggressiveness were selected for analysis of relative molecular weight 72,000-dalton type IV collagenase (gelatinase A) expression by mRNA in situ hybridization. Strong gelatinase A mRNA expression was seen in 10 of 14 follicular carcinomas, in none of six follicular adenomas, in all four anaplastic carcinomas, and in four of five papillary carcinomas. The expression was restricted to fibroblasts in the stroma adjacent or close to invading tumor cells. Twelve of the tumors were also investigated for expression of stromelysin 3 mRNA, no expression of which was detected in any tumor. The findings suggest that gelatinase A contributes to the invasive process and spread of aggressive thyroid tumors.: 1996 by the Société Internationale de Chir, ugie Zedenius Jan Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Ståhle-Bäckdahl Mona Department of Dermatology, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Enberg Ulla Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Grimelius Lars Department of Pathology, University Hospital, Uppsala, Sweden, SE aut Larsson Catharina Department of Molecular Medicine (Endocrine Tumor Unit), Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Wallin Göran Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Bäckdahl Martin Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut https://doi.org/10.1007/s002689900018 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zedenius Jan Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Ståhle-Bäckdahl Mona Department of Dermatology, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Enberg Ulla Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Grimelius Lars Department of Pathology, University Hospital, Uppsala, Sweden, SE aut NATIONALLICENCE 700 1- Larsson Catharina Department of Molecular Medicine (Endocrine Tumor Unit), Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Wallin Göran Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Bäckdahl Martin Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer