caa a22 4500 477034888 CHVBK 20180405111302.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002689900099 doi (NATIONALLICENCE)springer-10.1007/s002689900099 Lower Limb Intraarterial Thrombolysis as an Adjunct to the Management of Arterial and Graft Occlusions [Elektronische Daten] [Bruce D. Braithwaite, William J. Quiñones-Baldrich] Abstract. Intraarterial thrombolysis is used increasingly for management of arterial and bypass graft occlusions. Current research has been directed at the indications for and methods of catheter-directed thrombolysis. Streptokinase, urokinase, and tissue plasminogen activator (t-PA) are the most commonly used agents. They are administered by a variety of techniques and in various doses involving intrathrombic infusions, thrombus lacing, high-dose bolus therapy, and pulse-spray lysis. The latter methods appear to produce thrombolysis within a few hours, so this chemical therapy has the potential to become the first-line management for all episodes of acute limb ischemia. The role of thrombolysis is to return patients to their prethrombotic or preembolic state, so the underlying condition can be treated by radiologic intervention, surgery, or anticoagulation. Intraarterial thrombolysis is indicated for occlusions of less than 2 weeks' duration where the limb is able to withstand a period of further ischemia. Older occlusions should be treated by surgery, reserving intraoperative lysis for specific situations.: 1996 by the Société Internationale de Chir, ugie Braithwaite Bruce D. Department of Surgery, Section of Vascular Surgery, UCLA Center for the Health Sciences, UCLA Medical Center, 10833 Le Conte Avenue, 72-167 CHS, Los Angeles, California 90024-6904, U.S.A., US aut Quiñones-Baldrich William J. Department of Surgery, Section of Vascular Surgery, UCLA Center for the Health Sciences, UCLA Medical Center, 10833 Le Conte Avenue, 72-167 CHS, Los Angeles, California 90024-6904, U.S.A., US aut https://doi.org/10.1007/s002689900099 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900099 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Braithwaite Bruce D. Department of Surgery, Section of Vascular Surgery, UCLA Center for the Health Sciences, UCLA Medical Center, 10833 Le Conte Avenue, 72-167 CHS, Los Angeles, California 90024-6904, U.S.A., US aut NATIONALLICENCE 700 1- Quiñones-Baldrich William J. Department of Surgery, Section of Vascular Surgery, UCLA Center for the Health Sciences, UCLA Medical Center, 10833 Le Conte Avenue, 72-167 CHS, Los Angeles, California 90024-6904, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer