caa a22 4500 477035078 CHVBK 20180405111303.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/s002689900183 doi (NATIONALLICENCE)springer-10.1007/s002689900183 Clinical Development of Human Polymerized Hemoglobin as a Blood Substitute [Elektronische Daten] [Steven A. Gould, Gerald S. Moss] Abstract. Although the efficacy of hemoglobin-based oxygen carriers was established more than 60 years ago, all prior clinical trials have demonstrated significant toxicity characterized by renal dysfunction, gastrointestinal distress, and systemic vasoconstriction. The mechanisms of these toxicities now appear to be understood. Tetrameric forms of the hemoglobin molecule extravasate from the circulation and interact with endothelium-derived relaxing factor, leading to unopposed vasoconstriction. Although numerous efforts are under way to chemically modify the native tetramer, it is likely that all tetrameric forms of the hemoglobin molecule will continue to extravasate. We have focused on developing a polymerized form of hemoglobin that is virtually free of unreacted tetramer. The development and characterization of this polymerized pyridoxylated hemoglobin solution (Poly SFH-P) is described. Clinical trials have been completed successfully in volunteers and are now under way to assess the safety and efficacy of Poly SFH-P as a clinically useful red blood cell substitute for treatment of acute blood loss in the setting of trauma and surgery.: 1996 by the Société Internationale de Chir, ugie Gould Steven A. Department of Surgery, Columbia Michael Reese Hospital and Medical Center, 2929 S. Ellis Avenue, Chicago, Illinois 60616, U.S.A., US aut Moss Gerald S. Department of Surgery, University of Illinois, College of Medicine, 1853 W. Polk, Chicago, Illinois 60612, U.S.A., US aut https://doi.org/10.1007/s002689900183 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900183 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gould Steven A. Department of Surgery, Columbia Michael Reese Hospital and Medical Center, 2929 S. Ellis Avenue, Chicago, Illinois 60616, U.S.A., US aut NATIONALLICENCE 700 1- Moss Gerald S. Department of Surgery, University of Illinois, College of Medicine, 1853 W. Polk, Chicago, Illinois 60612, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer