caa a22 4500 477035248 CHVBK 20180405111303.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002689900140 doi (NATIONALLICENCE)springer-10.1007/s002689900140 Pheochromocytomas: Tendency to Degenerate and Cause Paroxysmal Hypertension [Elektronische Daten] [Yukio Ito, Takao Obara, Tomoyuki Yamashita, Masako Kanbe, Masatoshi Iihara] Abstract. Eighty-four patients with pheochromocytoma underwent surgery during the 13-year period from 1981 to 1994. These patients were divided into three groups according to the degree of parenchymal degeneration, which was estimated by preoperative dynamic computed tomography (CT) scans and resected specimens: solid group, cystic group, and highly cystic group. The relation between the degree of parenchymal degeneration and the clinical variety, size of the tumor, predominant plasma catecholamine, and type of blood pressure disturbance was analyzed. There were 39 cases of solid pheochromocytoma, 37 cases of cystic tumor, and 8 cases of highly cystic pheochromocytoma. The maximal mean diameters for each group were as follows: 5.1 ± 2.3, 6.8 ± 3.0, and 7.9 ± 3.2 cm, respectively. Of the tumors < 3 cm in diameter, 84% were solid; when the tumors were ≥ 6 cm in diameter, approximately 50% were cystic and 20% highly cystic. Of the adrenal pheochromocytomas, 60% were degenerated; 79% of the extraadrenal tumors were solid. Of the epinephrine-secreting tumors, 70% were degenerated, and 55% of the norepinephrine-secreting tumors were solid. The clinical pattern of hypertension was related to the degree of degeneration: In the paroxysmal hypertension group 87% of the tumors were degenerated, and in the sustained hypertension group 69% were solid. We therefore believe that parenchymal degeneration of pheochromocytoma is highly correlated with the tumor diameter, location of the tumor, secreted catecholamine, and clinical pattern of hypertension.: 1996 by the Société Internationale de Chir, ugie Ito Yukio Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut Obara Takao Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut Yamashita Tomoyuki Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut Kanbe Masako Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut Iihara Masatoshi Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut https://doi.org/10.1007/s002689900140 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900140 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ito Yukio Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Obara Takao Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Yamashita Tomoyuki Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Kanbe Masako Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Iihara Masatoshi Department of Endocrine Surgery, Tokyo Women's Medical College, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer