caa a22 4500 477035256 CHVBK 20180405111303.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002689900138 doi (NATIONALLICENCE)springer-10.1007/s002689900138 Metastatic Endocrine Tumors: Medical Treatment, Surgical Resection, or Liver Transplantation [Elektronische Daten] [Bertrand Dousset, Olivier Saint-Marc, Jol Pitre, Olivier Soubrane, Didier Houssin, Yves Chapuis] Abstract. We reviewed our experience with 34 patients with metastatic endocrine tumors (METs) who were treated by different modalities. Eight patients were treated by chemotherapy or chemoembolization because of stable disease or surgical contraindications. Seventeen patients underwent curative or cytoreductive surgical resection. Nine patients received grafts based on the following criteria: no extrahepatic spread on imaging workup and nonresectable symptomatic metastatic disease. Of the eight medically treated patients, the five patients with initial stable clinical condition are alive 32 to 56 months after referral. Of the 17 patients treated by liver resection, 13 are alive 6 to 108 months after surgery, and 7 are disease-free. After curative resection, the 5-year actuarial survival and disease-free survival rates were 62% and 52%, respectively. Of the nine grafted patients, three patients grafted for carcinoid tumor are alive at 15, 24, and 62 months, one of whom has a late recurrence. Our results indicate that therapeutic indications for METs should be based on age, clinical symptoms, histologic type, and tumor extension: Patients with stable MET may benefit from surgical restraint; liver resection in patients with aggressive MET may provide good long-term palliation and possibly cure one-third of the patients; liver transplantation should be restricted to young patients with nonresectable carcinoid MET but remains a high-risk operation because of previous surgery and chemoembolization.: 1996 by the Société Internationale de Chir, ugie Dousset Bertrand Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Saint-Marc Olivier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Pitre Jol Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Soubrane Olivier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Houssin Didier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Chapuis Yves Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut https://doi.org/10.1007/s002689900138 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900138 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dousset Bertrand Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut NATIONALLICENCE 700 1- Saint-Marc Olivier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut NATIONALLICENCE 700 1- Pitre Jol Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut NATIONALLICENCE 700 1- Soubrane Olivier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut NATIONALLICENCE 700 1- Houssin Didier Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut NATIONALLICENCE 700 1- Chapuis Yves Clinique Chirurgicale, Hôpital Cochin, 75679 Paris Cedex 14, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer