caa a22 4500 477035299 CHVBK 20180405111303.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002689900122 doi (NATIONALLICENCE)springer-10.1007/s002689900122 Preoperative Change of Thyroid Stimulating Hormone Receptor Antibody Level: Possible Marker for Predicting Recurrent Hyperthyroidism in Patients with Graves' Disease after Subtotal Thyroidectomy [Elektronische Daten] [Kiminori Sugino, Takashi Mimura, Osamu Ozaki, Hiroyuki Iwasaki, Nobuyuki Wada, Akihiko Matsumoto, Kunihiko Ito] Abstract. To make the surgical treatment for Graves' disease more ideal, it is important to elucidate factors related to postoperative thyroid dysfunction in addition to thyroid remnant. Because TSH receptor antibody (TRAb) is thought to be one of the essential causes of Graves' disease, we investigated whether preoperative changes in serum TRAb levels are related to postoperative recurrent hyperthyroidism. Between 1987 and 1992 a total of 1520 patients with Graves' disease were treated by subtotal thyroidectomy. Of these patients 335 visited Ito Hospital with no history of drug treatment of their disease and were treated surgically after several courses of antithyroid drug (ATD) therapy. There were 68 males and 267 females with a mean age of 25.8 years. The mean follow-up period was 48 months (range 12-84 months). Factors analyzed by univariate and multivariate analysis were as follows: age, sex, duration of ATD treatment, weight of resected thyroid, weight of thyroid remnant, preoperative titer of MCHA, TRAb at the time of initial examination (TRAb1), TRAb at the time of surgery (TRAb2), and ΔTRAb, the difference between TRAb1 and TRAb2 (ΔTRAb = TRAb1 − TRAb2). The chi-square test was used for univariate analysis and a logistic model for multivariate analysis. Of this group, 119 patients were euthyroid (35.5%), 50 were hyperthyroid (14.9%), and 166 were hypothyroid (49.3%). Significant factors related to recurrent hyperthyroidism were weight of thyroid remnant and ΔTRAb in both univariate and multivariate analyses. ΔTRAb is a possible new marker for predicting postoperative recurrent hyperthyroidism. If the preoperative TRAb level is not improved by ATDs in patients with Graves' disease, the thyroid remnant should be made smaller.: 1996 by the Société Internationale de Chir, ugie Sugino Kiminori Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut Mimura Takashi Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut Ozaki Osamu Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut Iwasaki Hiroyuki First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut Wada Nobuyuki First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut Matsumoto Akihiko First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut Ito Kunihiko Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut https://doi.org/10.1007/s002689900122 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900122 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugino Kiminori Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut NATIONALLICENCE 700 1- Mimura Takashi Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut NATIONALLICENCE 700 1- Ozaki Osamu Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut NATIONALLICENCE 700 1- Iwasaki Hiroyuki First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut NATIONALLICENCE 700 1- Wada Nobuyuki First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut NATIONALLICENCE 700 1- Matsumoto Akihiko First Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236, Japan, JP aut NATIONALLICENCE 700 1- Ito Kunihiko Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer