caa a22 4500 477035426 CHVBK 20180405111303.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002689900128 doi (NATIONALLICENCE)springer-10.1007/s002689900128 Two-Dimensional Proton Magnetic Resonance Spectroscopy for Tissue Characterization of Thyroid Neoplasms [Elektronische Daten] [Wanda B. Mackinnon, Leigh Delbridge, Peter Russell, Cynthia L. Lean, George L. May, Sinead Doran, Susan Dowd, Carolyn E. Mountford] Abstract. We have previously demonstrated that one dimensional (1D) proton (1H) magnetic resonance spectroscopy (MRS) can distinguish normal thyroid tissue from thyroid carcinoma using a spectral ratio of peak intensity at 1.7 ppm/0.9 ppm. Two dimensional (2D) 1H-MRS allows identification of specific molecules that have overlapping peaks in the 1D-MR spectrum. Specimens from 93 consecutive thyroid nodules were examined using 2D 1H-MRS on a Bruker AM-360 wide-bore spectrometer. There was a progressive increase in lipid cross peaks assigned to di-/triglycerides when comparing colloid/hyperplastic nodules to follicular adenoma, and adenoma to carcinoma. A specific cross peak attributable to cholesterol/cholesteryl esters was commonly seen in carcinomas. In contrast, two unassigned cross peaks unique to the thyroid were more prevalent in benign lesions. There was an overall increase in cross peaks attributable to cell surface fucosylation in carcinoma when compared to benign lesions, although the fucose spectral pattern was not specific for cancer. On this basis, a spectral ratio of peak intensity at 2.05 ppm/0.9 ppm more clearly distinguished benign follicular adenoma from carcinoma. 2D 1H-MRS thus identifies chemical changes that allow more specific tissue characterization of thyroid neoplasms.: 1996 by the Société Internationale de Chir, ugie Mackinnon Wanda B. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Delbridge Leigh Endocrine Surgical Unit, Royal North Shore Hospital, St. Leonards, New South Wales 2060, Australia, AU aut Russell Peter Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Lean Cynthia L. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut May George L. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Doran Sinead Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Dowd Susan Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Mountford Carolyn E. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut https://doi.org/10.1007/s002689900128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mackinnon Wanda B. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- Delbridge Leigh Endocrine Surgical Unit, Royal North Shore Hospital, St. Leonards, New South Wales 2060, Australia, AU aut NATIONALLICENCE 700 1- Russell Peter Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- Lean Cynthia L. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- May George L. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- Doran Sinead Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- Dowd Susan Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut NATIONALLICENCE 700 1- Mountford Carolyn E. Institute for Magnetic Resonance Research, Blackburn Building, D06, University of Sydney, Sydney, New South Wales 2006, Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer