caa a22 4500 477035523 CHVBK 20180405111304.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/s002689900057 doi (NATIONALLICENCE)springer-10.1007/s002689900057 Long-Term Observation of Serum Thyroglobulin after Resection of Nontoxic Goiter and Relation to Ultrasonographically Demonstrated Relapse [Elektronische Daten] [John Date, Ulla Feldt-Rasmussen, Mogens Blichert-Toft, Lazlo Hegedüs, Hans P. Graversen] Abstract. The object was to carry out a prospective study of the changes in serum thyroid hormones and thyroglobulin (Tg) following resection of nontoxic goiter and to investigate if there was a correlation to the pattern of relapse. A group of 39 consecutive patients, mainly with nodular, nontoxic goiter, were studied for 13 years following thyroidectomy. No thyroid hormone replacement therapy was given after surgery. The preoperative serum Tg level was elevated. After operation the mean serum Tg declined to a nadir of 43 μg/L at 1 year and subsequently increased to 90 μg/L at 10 years, with large individual differences. In 19 patients the serum Tg increased, in 1 it decreased, and in 19 no significant alteration was observed. Serum free thyroxine and triiodothyronine indices decreased following resection but achieved normal levels within 6 to 12 months. Serum thyroid-stimulating hormone increased after resection, with a peak level 1 month after surgery, but it returned to normal levels at 1 year and remained stable for the rest of the period. At 13 years after resection the thyroid volume was determined by ultrasonography in 30 of the patients. In 10 patients the thyroid volume was enlarged (≥ 28 ml). In this group a rise of average serum Tg after resection [ΔTg(10-1 year)] of 133 μg/L was observed, compared to 26 μg/L in the 20 patients without sonographic relapse (volume < 28 ml). A positive correlation was demonstrated between serum ΔTg(10-1 year) postsurgically and thyroid volume 13 years after surgery. However, an overlap was observed between the groups with and without ultrasonographic relapse, probably in part due to large differences in the Tg synthesis activity of different follicle cell clones. It is concluded that repeated serum Tg determinations may provide biochemical evidence of increased growth activity of thyroid remnants monitored after goiter resection.: 1996 by the Société Internationale de Chir, ugie Date John Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark, DK aut Feldt-Rasmussen Ulla Department of Endocrinology P, Rigshospitalet, 2100 Copenhagen, Denmark, DK aut Blichert-Toft Mogens Department of Endocrine Surgery D 2112, Rigshospitalet, 2100 Copenhagen, Denmark, DK aut Hegedüs Lazlo Department of Endocrinology M, Odense University Hospital, Odense, Denmark, DK aut Graversen Hans P. Department of Endocrine Surgery A, Odense University Hospital, Odense, Denmark, DK aut https://doi.org/10.1007/s002689900057 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900057 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Date John Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark, DK aut NATIONALLICENCE 700 1- Feldt-Rasmussen Ulla Department of Endocrinology P, Rigshospitalet, 2100 Copenhagen, Denmark, DK aut NATIONALLICENCE 700 1- Blichert-Toft Mogens Department of Endocrine Surgery D 2112, Rigshospitalet, 2100 Copenhagen, Denmark, DK aut NATIONALLICENCE 700 1- Hegedüs Lazlo Department of Endocrinology M, Odense University Hospital, Odense, Denmark, DK aut NATIONALLICENCE 700 1- Graversen Hans P. Department of Endocrine Surgery A, Odense University Hospital, Odense, Denmark, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer