caa a22 4500 477035795 CHVBK 20180405111304.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002689900070 doi (NATIONALLICENCE)springer-10.1007/s002689900070 Potential Strategies for Inflammatory Mediator Manipulation: Retrospect and Prospect [Elektronische Daten] [Jr., Charles J. Fisher, Yunli Zheng] Abstract. Sepsis syndrome and septic shock remain significant causes of morbidity and mortality. To date, clinical trials of novel agents to treat sepsis have failed to demonstrate clinical efficacy despite considerable animal data to suggest a positive therapeutic benefit. This article reviews the recent major clinical trials on sepsis and discusses the hypotheses on which these therapies are based and the critical issues associated with clinical sepsis. Recommendations for future clinical trials on sepsis are made.: 1996 by the Société Internationale de Chir, ugie Fisher Jr., Charles J. Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, U.S.A., US aut Zheng Yunli Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, U.S.A., US aut https://doi.org/10.1007/s002689900070 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900070 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fisher Jr., Charles J. Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, U.S.A., US aut NATIONALLICENCE 700 1- Zheng Yunli Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer