caa a22 4500 477035817 CHVBK 20180405111304.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002689900062 doi (NATIONALLICENCE)springer-10.1007/s002689900062 Early Risk Factors for Postinjury Multiple Organ Failure [Elektronische Daten] [Angela Sauaia, Frederick A. Moore, Ernest E. Moore, Dennis C. Lezotte] Abstract. Epidemiologic studies, based on retrospective data from heterogeneous populations with poor control of confounders, led early investigators to conclude that infection was the overriding risk factor for multiple organ failure (MOF). More recent studies have convincingly shown that MOF frequently occurs in the absence of infection. Consequently, we have shifted our research focus away from the traditional infectious models of MOF to the newer "one-hit” and "two-hit” inflammatory models. Clinically, we have chosen to study trauma patients because they are a relatively homogeneous group with a low incidence of common confounders. Trauma also permits a clear distinction between the first insult and the outcome, both temporally and with respect to the definition criteria. In this review we discuss the background, rationale, and our initial attempts to use indicators of the first insult (i.e., tissue injury quantification and clinical signs of shock) and indicators of the host response (i.e., systemic inflammatory response syndrome) to predict MOF early after injury.: 1996 by the Société Internationale de Chir, ugie Sauaia Angela Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut Moore Frederick A. Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut Moore Ernest E. Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut Lezotte Dennis C. Department of Preventive Medicine and Biometrics, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut https://doi.org/10.1007/s002689900062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sauaia Angela Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut NATIONALLICENCE 700 1- Moore Frederick A. Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut NATIONALLICENCE 700 1- Moore Ernest E. Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut NATIONALLICENCE 700 1- Lezotte Dennis C. Department of Preventive Medicine and Biometrics, Denver General Hospital, University of Colorado Health Sciences Center, 777 Bannock, Denver, Colorado 80204, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer