caa a22 4500 477035868 CHVBK 20180405111304.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002689900079 doi (NATIONALLICENCE)springer-10.1007/s002689900079 Protection of the Gastroduodenal Mucosa from the Effects of Diclofenac Sodium: Role of Highly Selective Vagotomy and Misoprostol [Elektronische Daten] [Athanasios D. Giannoukas, Georgios Baltoyiannis, Manolis Milonakis, Dimitrios Nastos, Lambros Papagikos, Angelos M. Kappas, Michalis Fatouros, Constantinos Papadimitriou, Diamantis Cassioumis] Abstract. The aim of this study was to determine the effectiveness of highly selective vagotomy (HSV) or misoprostol, a prostaglandin E1 (PGE1) analog, for protecting the gastroduodenal mucosa (GDM) from the effects of diclofenac sodium (DS). Fifty mongrel dogs were randomly allocated to five groups. HSV alone was performed in group I dogs (controls) to standardize the operation. DS was given intramuscularly for 12 consecutive days to the group II dogs, whereas in the group III dogs HSV was performed, followed a month later by DS administration, as in group II. DS was given in combination with misoprostol for 12 days to the group IV dogs. HSV was performed on the group V dogs, and a month later DS and misoprostol were given, as in group IV. After sacrificing the animals the GDM was examined for macroscopic and histologic lesions. Statistical analysis was made by Fisher's exact test. HSV alone did not protect the gastric or duodenal mucosa from the effects of DS (: p = 0.474 and p = 0.62, respectively). Misoprostol alone also did not offer significant protection to the gastric or the duodenal mucosa ( p = 0.08 and p = 0.65, respectively). The combination of HSV plus misoprostol protected the gastric mucosa (group V, p = 0.007) but not the duodenal mucosa (group V, p = 0.08). Hence HSV or misoprostol alone offers no protection to the GDM from the effects of DS. The combination of HSV and misoprostol offers significant protection only to gastric mucosa. Enhancement of the mucosal defense mechanisms combined with strong reduction of gastric acidity may offer adequate protection to gastric mucosa from the effects of nonsteroidal antiinflammatory drugs. 1996 by the Société Internationale de Chir, ugie Giannoukas Athanasios D. Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Baltoyiannis Georgios Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Milonakis Manolis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Nastos Dimitrios Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Papagikos Lambros Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Kappas Angelos M. Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Fatouros Michalis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Papadimitriou Constantinos Department of Histopathology, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Cassioumis Diamantis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut https://doi.org/10.1007/s002689900079 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900079 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giannoukas Athanasios D. Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Baltoyiannis Georgios Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Milonakis Manolis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Nastos Dimitrios Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Papagikos Lambros Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Kappas Angelos M. Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Fatouros Michalis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Papadimitriou Constantinos Department of Histopathology, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut NATIONALLICENCE 700 1- Cassioumis Diamantis Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer