caa a22 4500 477036058 CHVBK 20180405111305.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/s002689900165 doi (NATIONALLICENCE)springer-10.1007/s002689900165 Effect of Supplemental l -Arginine in a Chemical-Induced Model of Colorectal Cancer [Elektronische Daten] [Qingyong Ma, Margaret Hoper, Neil Anderson, Brian J. Rowlands] Abstract. l-Arginine inhibits the development of spontaneous, transplantable solid tumors and chemically induced mammary tumors. The aim of the present study was to investigate the effect of l-arginine on chemically induced colorectal cancer in male Wistar rats. Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2-dimethyhydrazine (DMH) at a dosage of 20 mg/kg body weight. Arginine was given in a 1% solution of drinking water. Group I was the DMH control; group II, arginine for 22 weeks; group III, arginine for the first 10 weeks only. Lymphocyte function was evaluated by measuring the thymic lymphocyte proliferative response to the T cell mitogen phytohemagglutinin. The results show that tumor incidence and tumor burden (tumors/rat and tumors/tumor-bearing rat) were significantly reduced in both groups of animals receiving arginine compared to DMH controls (p < 0.05). The tumor areas and volumes were also reduced in both arginine groups ( p < 0.05). Thymic lymphocyte stimulation indices were significantly increased by arginine supplementation ( p < 0.05). These results would be in keeping with the reduction in colorectal tumor production due to a "nonspecific” stimulation of the host immune system by l -arginine. : 1996 by the Société Internationale de Chir, ugie Ma Qingyong Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut Hoper Margaret Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut Anderson Neil Department of Pathology, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut Rowlands Brian J. Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut https://doi.org/10.1007/s002689900165 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900165 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ma Qingyong Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut NATIONALLICENCE 700 1- Hoper Margaret Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut NATIONALLICENCE 700 1- Anderson Neil Department of Pathology, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut NATIONALLICENCE 700 1- Rowlands Brian J. Department of Surgery, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, U.K., GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer