caa a22 4500 47703621X CHVBK 20180405111305.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/s002689900149 doi (NATIONALLICENCE)springer-10.1007/s002689900149 Intraabdominal Pressure and Gastric Intramucosal pH: Is There an Association? [Elektronische Daten] [M. Sugrue, F. Jones, Anna Lee, M.D. Buist, S. Deane, A. Bauman, K. Hillman] Abstract. This study evaluated the potential association between increased intraabdominal pressure (IAP) and abnormally low gastric intramucosal pH (pHi) (≤ 7.32) in postoperative patients and assessed its effect on patient outcome. Altogether 73 patients undergoing major abdominal surgery over a 9-month period were studied prospectively. All underwent gastric tonometry and intravesical IAP measurements three time daily. An IAP of ≥ 20 mmHg and a pHi of ≤ 7.32 were considered abnormal. The development of the following complications were also documented: hypotension [mean aortic pressure (MAP) < 80 mmHg], abdominal sepsis, renal impairment, and death. The median APACHE II score was 16 (range 5-34). Twenty-two patients had upper gastrointestinal (GI) surgery, 27 lower GI surgery, and 24 aortic surgery; 44 of these patients underwent emergency surgery. Abnormal pHi (≤ 7.32) occurred in 36 patients while on the intensive care unit. Compared to patients with normal pHi, abnormal pHi patients were 11.3 times (3.2-43.5) [odds ratio ± 95% CI] more likely to have an increased IAP. Abnormal pHi was significantly associated with hypotension (χ2 = 6.8;: p = 0.009), sepsis (χ 2 = 3.7; p = 0.06), renal impairment (χ 2 = 28.3; p = 0.0000001), relaparotomy (χ 2 = 4.1; p = 0.04), and death (χ 2 = 9.7; p = 0.002). This study demonstrated a significant clinical association between increased IAP and abnormal pHi. An abnormally low pHi was associated with poor outcome. 1996 by the Société Internationale de Chir, ugie Sugrue M. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Jones F. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Lee Anna Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Buist M.D. Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Deane S. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Bauman A. Department of Public Health, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Hillman K. Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut https://doi.org/10.1007/s002689900149 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900149 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugrue M. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Jones F. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Lee Anna Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Buist M.D. Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Deane S. Department of Surgery, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Bauman A. Department of Public Health, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut NATIONALLICENCE 700 1- Hillman K. Department of Intensive Care, Liverpool Hospital, Elizabeth Street, Liverpool, Sydney 2170, Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer